Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume
Leiserson WM, Forbush B, Keshishian H. Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume. Glia 2010, 59: 320-332. PMID: 21125654, PMCID: PMC3005002, DOI: 10.1002/glia.21103.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBlood-Nerve BarrierCells, CulturedDrosophilaDrosophila ProteinsExtracellular SpaceHumansIn Vitro TechniquesLarvaMicroscopy, Electron, TransmissionModels, BiologicalMutationNeural ConductionNeurogliaNeuronsPeripheral NervesProtein Serine-Threonine KinasesSymportersTwo-Hybrid System TechniquesConceptsHuman NKCC1Yeast two hybrid assaysExtracellular solute compositionLarvae mutantDrosophila gliaNcc69Osmotic homeostasisExtracellular volumeMolecular mechanismsNervous systemOrthologsExtracellular solutesPhysiological mechanismsBlood-brain barrierBlood-nerve barrierSimilar roleAccumulation of fluidAction potential conductionGlial cellsPeripheral neuropathyNKCC1Serious health threatDetectable impactBlood barrierGlia