2013
Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome
Wagner J, Allen K, Yang H, Nan B, Morishita M, Mukherjee B, Dvonch J, Spino C, Fink G, Rajagopalan S, Sun Q, Brook R, Harkema J. Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome. Environmental Health Perspectives 2013, 122: 27-33. PMID: 24169565, PMCID: PMC3888573, DOI: 10.1289/ehp.1307085.Peer-Reviewed Original ResearchConceptsHFrD ratsBlood pressureND ratsHeart rateMetabolic syndromeHR variabilityFasting levels of blood glucoseNormal dietMale Sprague-Dawley ratsParticulate matterAssociated with cardiovascular morbidityCardiovascular depressionAir pollutionSprague-Dawley ratsDiet-induced metabolic syndromeElevated fasting levelsToxicity of air pollutantsFine particulate matterHigh-fructose dietLevels of blood glucoseInhalable particulate matterLevels of ozoneInduce MetSCardiovascular morbidityExaggerated BP
2011
PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio
Kamal A, Rohr A, Mukherjee B, Morishita M, Keeler G, Harkema J, Wagner J. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhalation Toxicology 2011, 23: 417-430. PMID: 21639710, DOI: 10.3109/08958378.2011.580387.Peer-Reviewed Original ResearchConceptsNE windsSW windsSource factorsMobile source factorsPositive matrix factorizationConcentrated ambient particlesPotential emission sourcesSources of PM(2.5Adverse health effectsPM constituentsWind directionParticulate matterMobile sourcesIndividual elemental componentsTrace elementsAmbient particlesIron/steel productionPM(2.5IncinerationAmbient PM(2.5Metal factorWindHealth effectsExposure to concentrated ambient particlesSouthwest
2010
Altered Heart Rate Variability in Spontaneously Hypertensive Rats Is Associated with Specific Particulate Matter Components in Detroit, Michigan
Rohr A, Kamal A, Morishita M, Mukherjee B, Keeler G, Harkema J, Wagner J. Altered Heart Rate Variability in Spontaneously Hypertensive Rats Is Associated with Specific Particulate Matter Components in Detroit, Michigan. Environmental Health Perspectives 2010, 119: 474-480. PMID: 21163724, PMCID: PMC3080928, DOI: 10.1289/ehp.1002831.Peer-Reviewed Original ResearchConceptsSource factorsPositive matrix factorizationNormal-to-normal intervalsLocal industrial sourcesParticulate matter componentsFine particulate matterSludge factorSemicontinuous ElementsSludge incinerationAerosol samplerAdverse cardiopulmonary health effectsAmbient particlesHeart rate variabilityExposure to fine particulate matterParticulate matterSulfation factorWinterRoot mean squareIndustrial sourcesIncreased root mean squareSummerCement/limeAnalytical resultsHeart rateSludge