2018
Impact of community respiratory viral infections in urban children with asthma
Lewis T, Metitiri E, Mentz G, Ren X, Goldsmith A, Eder B, Wicklund K, Walsh M, Comstock A, Ricci J, Brennan S, Washington G, Owens K, Mukherjee B, Robins T, Batterman S, Hershenson M, SteeringCommittee T. Impact of community respiratory viral infections in urban children with asthma. Annals Of Allergy Asthma & Immunology 2018, 122: 175-183.e2. PMID: 30385348, PMCID: PMC6360098, DOI: 10.1016/j.anai.2018.10.021.Peer-Reviewed Original ResearchConceptsRespiratory viral infectionsViral infectionBiomarker elevationAirway functionSymptom scoresUpper respiratory tract viral infectionC-C motif chemokine ligand (CCL)-2Fraction of exhaled nitric oxideRespiratory tract viral infectionsRespiratory illnessUpper respiratory viral infectionReduced airway functionC-X-C motif chemokine ligandUpper respiratory tract symptomsExhaled nitric oxideMelanoma differentiation-associated protein 5Respiratory tract symptomsRespiratory tract inflammationCold-like illnessMotif chemokine ligandNormal airway functionSelf-reported respiratory illnessChemokine levelsForced expiratory flowNasal biomarkers
2015
Applying Novel Methods for Assessing Individual- and Neighborhood-Level Social and Psychosocial Environment Interactions with Genetic Factors in the Prediction of Depressive Symptoms in the Multi-Ethnic Study of Atherosclerosis
Ware E, Smith J, Mukherjee B, Lee S, Kardia S, Diez-Roux A. Applying Novel Methods for Assessing Individual- and Neighborhood-Level Social and Psychosocial Environment Interactions with Genetic Factors in the Prediction of Depressive Symptoms in the Multi-Ethnic Study of Atherosclerosis. Behavior Genetics 2015, 46: 89-99. PMID: 26254610, PMCID: PMC4720563, DOI: 10.1007/s10519-015-9734-6.Peer-Reviewed Original ResearchConceptsDepressive symptom scoresMulti-Ethnic Study of AtherosclerosisGene regionNeighborhood levelMulti-Ethnic StudyPredictive of depressive symptomsStudy of AtherosclerosisMultiple race/ethnicitiesMultiple testing correctionAssess individual-SKAT analysisNeighborhood factorsEtiology of depressive illnessDepressive symptomsPsychosocial stressorsSymptom scoresComplex illnessTesting correctionRace/ethnicityRace/ethnicitiesEthnic groupsDepressive illnessGenetic predispositionIndividual-Genetic factors
2012
Nasal cytokine responses to natural colds in asthmatic children
Lewis T, Henderson T, Carpenter A, Ramirez I, McHenry C, Goldsmith A, Ren X, Mentz G, Mukherjee B, Robins T, Joiner T, Mohammad L, Nguyen E, Burns M, Burke D, Hershenson M. Nasal cytokine responses to natural colds in asthmatic children. Clinical & Experimental Allergy 2012, 42: 1734-1744. PMID: 23181789, PMCID: PMC4219353, DOI: 10.1111/cea.12005.Peer-Reviewed Original ResearchConceptsViral infectionMarker elevationSymptom scoresMarkers of viral infectionRespiratory viral infectionsRobust innate immune responsePresence of viral infectionRespiratory symptom scoresMultiplex immune assaysRespiratory tract symptomsSelf-reported respiratory illnessCCL11/eotaxin-1IFN-responsive genesInnate immune responseWeeks of assessmentNasal aspiratesCXCL10/IP-10CCL7/MCP-3IFN-gCCL2/MCP-1IRF7 mRNACXCL8/IL-8Asthma exacerbationsImmune responseMRNA signal