2018
Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes
Yu Y, Xia L, Lee S, Zhou X, Stringham H, Boehnke M, Mukherjee B. Subset-Based Analysis Using Gene-Environment Interactions for Discovery of Genetic Associations across Multiple Studies or Phenotypes. Human Heredity 2018, 83: 283-314. PMID: 31132756, PMCID: PMC7034441, DOI: 10.1159/000496867.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCholesterolCohort StudiesComputer SimulationC-Reactive ProteinFinlandGene FrequencyGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLipoproteins, LDLMeta-Analysis as TopicModels, GeneticPhenotypePolymorphism, Single NucleotideConceptsPresence of G-E interactionsGenetic associationHeterogeneity of genetic effectsDiscovery of genetic associationsGene-environment (G-EMarginal genetic effectsG-E interactionsGenome-wide association studiesGene-environment interactionsGenetic effectsData examplesSimulation studySingle nucleotide polymorphismsGene-environmentAssociation studiesAssociation analysisScreening toolMarginal associationNucleotide polymorphismsPresence of heterogeneityAssociationEnvironmental factorsIncreased powerMultiple studiesG-E
2013
Novel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data
Ko Y, Saha‐Chaudhuri P, Park S, Vokonas P, Mukherjee B. Novel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data. Genetic Epidemiology 2013, 37: 581-591. PMID: 23798480, PMCID: PMC4009698, DOI: 10.1002/gepi.21744.Peer-Reviewed Original ResearchConceptsGene-environment interactionsGene-gene interactionsTesting gene-gene interactionsModel gene-gene interactionsRepeated-measures studyLongitudinal cohort studyNormative Aging StudyCumulative lead exposureCase-control studyGene-environmentGene-geneType I error rateCohort studyScreening toolAging StudyLikelihood ratio testMain effectEpistasis patternsRatio testLead exposureHemochromatosis genePower propertiesPulse pressureRegression-based approachRestrictive assumptions