Featured Publications
Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
Gu T, Mack J, Salvatore M, Sankar S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System. JAMA Network Open 2020, 3: e2025197. PMID: 33084902, PMCID: PMC7578774, DOI: 10.1001/jamanetworkopen.2020.25197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBetacoronavirusBlack or African AmericanComorbidityCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHealth Status DisparitiesHospitalizationHumansIntensive Care UnitsKidney DiseasesMaleMichiganMiddle AgedNeoplasmsObesityOdds RatioPandemicsPneumonia, ViralPopulation DensityRetrospective StudiesRisk FactorsSARS-CoV-2White PeopleConceptsAssociated with higher riskInternational Classification of DiseasesRisk of hospitalizationPreexisting type 2 diabetesHigher risk of hospitalizationClassification of DiseasesType 2 diabetesCOVID-19 outcomesRacial/ethnic disparitiesWhite patientsBlack patientsIntensive care unitInternational ClassificationResidential-level socioeconomic characteristicsOdds ratioStatistically significant racial differencesHigh riskAssociated with higher risk of hospitalizationNon-Hispanic blacksAssociation of risk factorsNon-Hispanic whitesMichigan Department of HealthAssociated with increased risk of hospitalizationComorbidity scoreDepartment of Health
2023
Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation
Kang H, Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Park S. Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation. Environmental Health Perspectives 2023, 131: 087004. PMID: 37552133, PMCID: PMC10408595, DOI: 10.1289/ehp12351.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthOdds ratioWomen's HealthMidlife womenConfidence intervalsFavorable blood lipid profileEstimate odds ratiosAdverse effects of PFASSerum PFAS concentrationsLatent class growth modelingLongitudinal trajectoriesAssociated with totalMenopausal transitionAssociated with trajectoriesLow-density lipoprotein (LDL) cholesterolHigh-density lipoprotein (HDL) cholesterolLipid trajectoriesAverage follow-upBlood total cholesterolBlood lipid profileTriglycerides trajectoriesEpidemiological studiesPositive associationBlood lipidsLDL cholesterol
2021
Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association
Khoja L, Weber RP, Group T, Webb PM, Jordan SJ, Muthukumar A, Chang-Claude J, Fortner RT, Jensen A, Kjaer SK, Risch H, Doherty JA, Harris HR, Goodman MT, Modugno F, Moysich K, Berchuck A, Schildkraut JM, Cramer D, Terry KL, Anton-Culver H, Ziogas A, Phung MT, Hanley GE, Wu AH, Mukherjee B, McLean K, Cho K, Pike MC, Pearce CL, Lee AW. Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association. Gynecologic Oncology 2021, 164: 195-201. PMID: 34776242, PMCID: PMC9444325, DOI: 10.1016/j.ygyno.2021.10.088.Peer-Reviewed Original ResearchConceptsHistory of endometriosisOvarian cancer riskEPT useOvarian Cancer Association ConsortiumOvarian cancerInverse associationOdds ratioCancer riskCancer associationInvasive epithelial ovarian cancerHormone therapy useMenopausal hormone therapyEpithelial ovarian cancerCase-control studyConfidence intervalsSlight inverse associationWarrants further investigationHormone therapyTherapy usePooled analysisEndometriosisHysterectomyCancerTherapySelf-reported dataChanges in COVID-19-related outcomes, potential risk factors and disparities over time
Yu Y, Gu T, Valley T, Mukherjee B, Fritsche L. Changes in COVID-19-related outcomes, potential risk factors and disparities over time. Epidemiology And Infection 2021, 149: e192. PMCID: PMC8376857, DOI: 10.1017/s0950268821001898.Peer-Reviewed Original ResearchIntensive care unit admission ratePotential risk factorsHospitalisation ratesAdmission ratesIntensive care unitCOVID-19-positive cohortCOVID-19-related hospitalisationMichigan MedicineResidential-level socioeconomic characteristicsOdds ratioRisk factorsTime-stratified analysisT1 to T3Impact of potential risk factorsInvestigate temporal trendsCOVID-19-related outcomesRetrospective cohort studySocioeconomic statusRacial disparitiesCalendar timeCohort studySocioeconomic characteristicsHospitalisationBlack patientsComorbid conditionsPerformance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting
Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting. Environmental Research 2021, 200: 111435. PMID: 34097892, PMCID: PMC8403638, DOI: 10.1016/j.envres.2021.111435.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreIntraclass correlation coefficientBirth outcomesBody mass indexWeighted quantile sumOdds ratio of preterm birthSecond-hand smoke exposurePre-pregnancy body mass indexOdds of preterm birthAssociated with birth outcomesIncreased odds of preterm birthPractice study designHealth effectsPreterm birthMaternal educationIncreased oddsOdds ratioSmoke exposureStudy designMaternal ageMass indexArea under the curveRisk scoreLogistic regressionConfidence intervalsPsychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes
Ashrap P, Aker A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021, 149: 106418. PMID: 33548848, PMCID: PMC7897320, DOI: 10.1016/j.envint.2021.106418.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesPsychosocial statusBirth outcomesBody mass indexPsychosocial stressPreterm birthOdds ratioAssociated with adverse birth outcomesPre-pregnancy body mass indexSecond-hand smoke exposurePrenatal psychosocial stressPregnant womenBlood metalsClusters of womenEffects of psychosocial stressPuerto Rico TestsiteIncreased odds ratioSocial supportPerceived stressMaternal educationAdverse associationOverall preterm birthLow birth weightSpontaneous preterm birthCohort study
2020
Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies
Lee AW, Rosenzweig S, Wiensch A, Group T, Ramus SJ, Menon U, Gentry-Maharaj A, Ziogas A, Anton-Culver H, Whittemore AS, Sieh W, Rothstein JH, McGuire V, Wentzensen N, Bandera EV, Qin B, Terry KL, Cramer DW, Titus L, Schildkraut JM, Berchuck A, Goode EL, Kjaer SK, Jensen A, Jordan SJ, Ness RB, Modugno F, Moysich K, Thompson PJ, Goodman MT, Carney ME, Chang-Claude J, Rossing MA, Harris HR, Doherty JA, Risch HA, Khoja L, Alimujiang A, Phung MT, Brieger K, Mukherjee B, Pharoah PDP, Wu AH, Pike MC, Webb PM, Pearce CL. Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies. Journal Of The National Cancer Institute 2020, 113: 301-308. PMID: 32766851, PMCID: PMC7936053, DOI: 10.1093/jnci/djaa099.Peer-Reviewed Original ResearchConceptsOvarian cancer riskInvasive epithelial ovarian cancerClear cell ovarian cancerIncomplete pregnanciesEpithelial ovarian cancerOvarian cancerOvarian Cancer Association ConsortiumCancer riskOdds ratioInvasive epithelial ovarian cancer casesEpithelial ovarian cancer casesHistotype-specific analysesHistotype-specific associationsOral contraceptive useInvasive ovarian cancerHistory of breastfeedingConfidence intervalsOvarian cancer casesCase-control studyOCAC studiesMajor histotypesPooled analysisInverse associationCancer casesComplete pregnancy
2019
A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants
Kim S, Wang M, Tyrer J, Jensen A, Wiensch A, Liu G, Lee A, Ness R, Salvatore M, Tworoger S, Whittemore A, Anton‐Culver H, Sieh W, Olson S, Berchuck A, Goode E, Goodman M, Doherty J, Chenevix‐Trench G, Rossing M, Webb P, Giles G, Terry K, Ziogas A, Fortner R, Menon U, Gayther S, Wu A, Song H, Brooks‐Wilson A, Bandera E, Cook L, Cramer D, Milne R, Winham S, Kjaer S, Modugno F, Thompson P, Chang‐Claude J, Harris H, Schildkraut J, Le N, Wentzensen N, Trabert B, Høgdall E, Huntsman D, Pike M, Pharoah P, Pearce C, Mukherjee B. A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants. International Journal Of Cancer 2019, 144: 2192-2205. PMID: 30499236, PMCID: PMC6399057, DOI: 10.1002/ijc.32029.Peer-Reviewed Original ResearchConceptsOral contraceptive pill useExcess risk due to additive interactionOvarian cancer risk factorsOral contraceptive pillsGene-environment interaction analysisCancer risk factorsGene-environment analysisOvarian cancer casesOCP useCase-control studyGenome-wide association analysisAdditive scaleCancer casesOvarian cancerOdds ratioCommon variantsDuration of OCP useRisk allelesRisk factorsGenetic variantsAdditive interactionAssociation analysisWomenFollow-upC allele
2017
Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES
Park S, Zhao Z, Mukherjee B. Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES. Environmental Health 2017, 16: 102. PMID: 28950902, PMCID: PMC5615812, DOI: 10.1186/s12940-017-0310-9.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreBayesian kernel machine regressionNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRisk scoreAssociated with odds ratiosNutrition Examination SurveyAssociated with systolicExamination SurveyMulti-pollutant approachKernel machine regressionPollutant mixturesSD increaseEpidemiological researchDiastolic blood pressureMortality outcomesOdds ratioBayesian additive regression treesDisease endpointsHealth endpointsCumulative riskPositive associationEnvironmental exposuresIntermediate markersCardiovascular disease
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociation
2014
Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70: 118-124. PMID: 24934852, PMCID: PMC4104181, DOI: 10.1016/j.envint.2014.05.016.Peer-Reviewed Original ResearchConceptsAdjusted odds ratiosUrinary phthalate metabolite levelsPreterm birthPhthalate metabolite levelsOdds ratioOdds of preterm birthAssociated with increased odds of preterm birthIncreased risk of delivering pretermCases of preterm birthWeeks of completed gestationRisk of delivering pretermAssociated with increased oddsMetabolite levelsPresentation of preeclampsiaSignificant public health problemSpontaneous preterm birthIntrauterine growth restrictionLongitudinal birth cohortPhthalate metabolite concentrationsPublic health problemBirth outcomesBirth cohortGrowth restrictionThird trimesterPregnant women
2011
Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan
Li S, Batterman S, Wasilevich E, Elasaad H, Wahl R, Mukherjee B. Asthma exacerbation and proximity of residence to major roads: a population-based matched case-control study among the pediatric Medicaid population in Detroit, Michigan. Environmental Health 2011, 10: 34. PMID: 21513554, PMCID: PMC3224543, DOI: 10.1186/1476-069x-10-34.Peer-Reviewed Original ResearchConceptsConditional logistic regressionPopulation-based matched case-control studyPediatric Medicaid populationCase-control studyMedicaid populationProximity of residenceLogistic regressionConditional logistic regression modelsElevated risk of asthmaRisk of asthmaEmergency department visitsCase-control analysisLogistic regression modelsHigh-risk populationTraffic-related pollutantsAsthma outcomesDepartment visitsAsthma eventsAsthma claimAsthma-related eventsAsthma casesEcological biasOdds ratioInvestigate associationsMethodThis study
2006
A Score Test for Determining Sample Size in Matched Case‐Control Studies with Categorical Exposure
Sinha S, Mukherjee B. A Score Test for Determining Sample Size in Matched Case‐Control Studies with Categorical Exposure. Biometrical Journal 2006, 48: 35-53. PMID: 16544811, DOI: 10.1002/bimj.200510200.Peer-Reviewed Original ResearchConceptsCase-control studyCategorical exposureMatched case-control studyScore testDichotomous exposureNull hypothesisExposure variablesOdds ratioNatural orderDisease-gene associationsMatched setsDisease riskColorectal cancerPower functionSample sizeAssociationOddsGeneralizationDiseaseSetsScoresEstimationExposureStudyRisk