Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease
Curry DW, Stutz B, Andrews ZB, Elsworth JD. Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease. Journal Of Parkinson's Disease 2018, 8: 161-181. PMID: 29614701, PMCID: PMC6004921, DOI: 10.3233/jpd-171296.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-SynucleinAMP-Activated Protein KinasesAnimalsAutophagyBrainDopaminergic NeuronsHumansNeuroprotective AgentsParkinson DiseaseSignal TransductionConceptsSerine/threonine kinaseFunction of AMPKParkinson's diseaseCellular energy balanceThreonine kinaseCellular stressorsIntracellular α-synuclein aggregatesProtein kinaseAMPK activationAMPK activityNumerous dietary supplementsPreclinical PD modelsNigrostriatal dopaminergic neuronsBroad neuroprotective effectsCell deathCommon neurodegenerative disorderAMPKΑ-synuclein aggregatesNeuroprotective treatmentNeuroprotective strategiesNeuroprotective effectsNeuronal atrophyPD patientsDopaminergic neuronsKinase