Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease
Curry DW, Stutz B, Andrews ZB, Elsworth JD. Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease. Journal Of Parkinson's Disease 2018, 8: 161-181. PMID: 29614701, PMCID: PMC6004921, DOI: 10.3233/jpd-171296.Peer-Reviewed Original ResearchConceptsSerine/threonine kinaseFunction of AMPKParkinson's diseaseCellular energy balanceThreonine kinaseCellular stressorsIntracellular α-synuclein aggregatesProtein kinaseAMPK activationAMPK activityNumerous dietary supplementsPreclinical PD modelsNigrostriatal dopaminergic neuronsBroad neuroprotective effectsCell deathCommon neurodegenerative disorderAMPKΑ-synuclein aggregatesNeuroprotective treatmentNeuroprotective strategiesNeuroprotective effectsNeuronal atrophyPD patientsDopaminergic neuronsKinaseAltered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology
Stoiljkovic M, Kelley C, Stutz B, Horvath TL, Hajós M. Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology. Cerebral Cortex 2018, 29: 2716-2727. PMID: 29920597, PMCID: PMC7302691, DOI: 10.1093/cercor/bhy140.Peer-Reviewed Original ResearchConceptsTgF344-AD ratsHippocampal theta oscillationsAlzheimer's diseaseDisease pathologyTheta-phase gamma-amplitude couplingAge-matched wild-type counterpartsAD pathological featuresDisease-modifying therapiesAccumulation of amyloidPredictive animal modelsAlzheimer's disease pathologyHigh-voltage spindlesTheta oscillationsSignificant age-dependent declineAge-dependent declineHippocampal excitabilitySharp-wave ripplesAβ accumulationNeuronal lossAD ratsPathological featuresUrethane anesthesiaAD patientsAuditory gatingAD drugs