2010
Low-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: A randomized trial
Toll BA, White M, Wu R, Meandzija B, Jatlow P, Makuch R, O’Malley S. Low-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: A randomized trial. Drug And Alcohol Dependence 2010, 111: 200-206. PMID: 20542391, PMCID: PMC3771701, DOI: 10.1016/j.drugalcdep.2010.04.015.Peer-Reviewed Original ResearchConceptsWeight gainSmoking cessationPoint prevalence smoking abstinence ratePre-specified primary outcomesLow-dose naltrexoneOpen-label therapySmoking abstinence ratesPoint prevalence abstinenceReduced weight gainNaltrexone augmentationPlacebo groupNicotine replacementPrimary outcomeQuit dateAbstinence ratesLabel therapyNicotine patchBehavioral counselingNaltrexoneAbstinent participantsSmokersWeight concernsWeeksCessationLower rates
2007
A preliminary investigation of naltrexone augmentation of bupropion to stop smoking with less weight gain
Toll BA, Leary V, Wu R, Salovey P, Meandzija B, O'Malley SS. A preliminary investigation of naltrexone augmentation of bupropion to stop smoking with less weight gain. Addictive Behaviors 2007, 33: 173-179. PMID: 17587504, PMCID: PMC2488403, DOI: 10.1016/j.addbeh.2007.05.012.Peer-Reviewed Original ResearchConceptsPost-cessation weight gainWeight-concerned smokersPoint prevalence abstinenceWeight gainAbstinent participantsSustained-release bupropion hydrochlorideHigher smoking cessation ratesWeight suppressant effectsOpen-label studyPercentage of patientsSmoking cessation ratesLess weight gainDays of treatmentNaltrexone augmentationAdverse eventsCombination pharmacotherapyPrimary outcomeCessation ratesTreatment regimenCigarette smokersClinical trialsContinuous abstinenceLabel studyPsychosocial interventionsBupropion