2022
Oncologic outcomes of neoadjuvant chemotherapy in patients with micropapillary variant urothelial carcinoma of the bladder
Rahman S, Lokeshwar S, Syed J, Javier-Desloges J, Press B, Choksi A, Rajwa P, Pradere B, Ploussard G, Kim J, Monaghan T, Renzulli J, Shariat S, Leapman M. Oncologic outcomes of neoadjuvant chemotherapy in patients with micropapillary variant urothelial carcinoma of the bladder. Urologic Oncology Seminars And Original Investigations 2022, 41: 107.e1-107.e8. PMID: 36481253, DOI: 10.1016/j.urolonc.2022.09.008.Peer-Reviewed Original ResearchConceptsVariant urothelial carcinomaNeoadjuvant chemotherapySubset of patientsUrothelial carcinomaOverall survivalPathologic responseRadical cystectomyNAC useClinical stage II diseaseHospital-based registry studyNeoadjuvant platinum-based chemotherapyPathologic lymph node positivityCox proportional hazards modelNational Cancer DatabaseStage II diseaseLymph node positivityPathologic complete responsePlatinum-based chemotherapyKaplan-Meier analysisMultivariable logistic regressionAnalysis of patientsBladder urothelial carcinomaProportional hazards modelCT2 diseasePathologic upstaging
2021
Utility of PSA Density in Predicting Upgraded Gleason Score in Men on Active Surveillance With Negative MRI
Press BH, Khajir G, Ghabili K, Leung C, Fan RE, Wang NN, Leapman MS, Sonn GA, Sprenkle PC. Utility of PSA Density in Predicting Upgraded Gleason Score in Men on Active Surveillance With Negative MRI. Urology 2021, 155: 96-100. PMID: 34087311, DOI: 10.1016/j.urology.2021.05.035.Peer-Reviewed Original ResearchConceptsPSA densityActive surveillanceConfirmatory biopsyPathologic upgradeNegative MRIProstate volumeProstate cancerFavorable intermediate-risk prostate cancerNegative baselineIntermediate-risk prostate cancerLow-grade prostate cancerLower prostate volumeMedian PSA densityNormal baseline MRIUpgraded Gleason scoreCohort of patientsSubset of patientsLarge academic centerPI-RADS 2Intensity of surveillanceAbility of PSABiopsy upgradeGG1 cancerGleason upgradeMedian PSA