2024
Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway
Vageli D, Doukas P, Judson B. Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway. JCO Global Oncology 2024, 10: 52-52. DOI: 10.1200/go-24-47000.Peer-Reviewed Original ResearchSerum miRNAsPanel of miRNAsHsa-miR-7704Oral squamous cell carcinomaSmall non-coding RNA sequencesHealthy controlsSerum of OSCC patientsMiRNAsMRNA markersOral cavity cancer patientsMRNA signatureDetection of oral cancerOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaNon-invasive biomarkersSerum samplesUnique miRNAsOral cancer detectionPost-treatment monitoringCell carcinomaOral cancerNon-coding RNA sequencesOSCC patientsCancer patientsNovel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway
Vageli D, Doukas P, Townsend J, Pickering C, Judson B. Novel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway. Cancer Medicine 2024, 13: e7309. PMID: 38819439, PMCID: PMC11141334, DOI: 10.1002/cam4.7309.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedMouth NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerRNA, Small UntranslatedSalivaSequence Analysis, RNASignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsOral squamous cell carcinomaPost-treatment monitoringHealthy controlsOral cavity cancer patientsOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaPatients relative to HCSamples of salivaMonitoring of patientsCell carcinomaPost-treatment monitoring of patientsSmoking historySerum miRNAsCancer patientsEfficient clinical toolEffective preventive careTherapeutic approachesMRNA signatureRNA sequencing analysisClinical testingSerumPatientsMolecular biomarkersClinical tool
2023
Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma
Shah R, Liu C, Shah H, Judson B. Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma. Laryngoscope Investigative Otolaryngology 2023, 8: 870-875. PMID: 37621277, PMCID: PMC10446262, DOI: 10.1002/lio2.1094.Peer-Reviewed Original ResearchOral cavity squamous cell carcinomaAbsolute lymphocyte countOral cavity cancerSquamous cell carcinomaRate of deathLikelihood of recurrenceLymphocyte countPrognostic valueCell carcinomaCancer patientsPreoperative absolute lymphocyte countPretreatment absolute lymphocyte countLate-stage cancer patientsRetrospective chart reviewAmerican Joint CommitteeDay of surgeryEarly-stage cancer patientsTumor registry dataAdjuvant therapyOutcome patientsChart reviewPrimary outcomeALC valuesPositive marginsPrognostic indicator
2020
Results of COVID-minimal Surgical Pathway During Surge-phase of COVID-19 Pandemic
Boffa DJ, Judson BL, Billingsley KG, Del Rossi E, Hindinger K, Walters S, Ermer T, Ratner E, Mitchell MR, Laurans MS, Johnson DC, Yoo PS, Morton JM, Zurich HB, Davis K, Ahuja N. Results of COVID-minimal Surgical Pathway During Surge-phase of COVID-19 Pandemic. Annals Of Surgery 2020, 272: e316-e320. PMID: 33086321, PMCID: PMC7668334, DOI: 10.1097/sla.0000000000004455.Peer-Reviewed Original ResearchConceptsHospital-acquired COVID-19 infectionCOVID-19 infectionSurgical pathwayCOVID-19 hospital admissionsCOVID-19 pandemicCommon surgical indicationsUrgent cancer treatmentOutcomes of patientsCOVID-19 patientsCOVID-19 testingCOVID-19 positive peoplePathway patientsPostoperative periodTimely surgeryHospital admissionMedian ageSurgical indicationsUrgent operationMedian lengthCancer patientsGenitourinary tractEmergency roomBACKGROUND DATASurgical proceduresPatient status
2019
Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy
LOGANADANE G, KANN BH, PARK HS, JOHNSON SB, MEHRA S, JUDSON BL, BHATIA A, BELKACEMI Y, YARBROUGH WG, BURTNESS B, HUSAIN ZA. Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy. Anticancer Research 2019, 39: 4885-4890. PMID: 31519591, DOI: 10.21873/anticanres.13674.Peer-Reviewed Original ResearchConceptsLocoregional recurrence-free survivalAdjuvant therapyNeck squamous cell carcinomaOutcomes of patientsRecurrence-free survivalSquamous cell carcinomaNeck cancer patientsHNSCC patientsClinical outcomesRecurrence rateCell carcinomaMean TTPCancer patientsPatientsTherapyResectionMonthsOutcomesHNSCCSurgeryCarcinomaHeadIncidenceProgression
2015
Refusal of postoperative radiotherapy and its association with survival in head and neck cancer
Schwam ZG, Husain Z, Judson BL. Refusal of postoperative radiotherapy and its association with survival in head and neck cancer. Radiotherapy And Oncology 2015, 117: 343-350. PMID: 26508285, DOI: 10.1016/j.radonc.2015.10.013.Peer-Reviewed Original ResearchConceptsNeck cancer patientsPostoperative radiotherapyPredictive factorsCancer patientsOverall survivalNegative nodesThree-year overall survivalCox proportional hazards analysisNational Cancer DatabaseProportional hazards analysisLong-term outcomesMultivariable logistic regressionSlow disease progressionCharlson scorePathologic variablesImproved survivalKaplan-MeierNeck cancerCancer DatabaseDisease progressionRetrospective analysisMultivariate analysisPatientsLogistic regressionSelect head
2014
Factors Associated with the Use of Intensity‐Modulated Radiotherapy for Head and Neck Cancer
Chen M, Roman S, Sosa J, Judson B. Factors Associated with the Use of Intensity‐Modulated Radiotherapy for Head and Neck Cancer. Otolaryngology 2014, 151: p164-p164. DOI: 10.1177/0194599814541629a85.Peer-Reviewed Original ResearchIntensity-modulated radiotherapyNeck cancer patientsConcurrent chemotherapyPostoperative radiotherapyCancer patientsPostoperative intensity-modulated radiotherapyNational Cancer DatabaseProportion of patientsHuman papillomavirus positivityHospital-level variationNeck cancer treatmentStudent's t-testClinical characteristicsNeck cancerCancer DatabasePractice patternsRetrospective analysisMAIN OUTCOMEWhite raceAcademic centersPrimary modalityMultivariate analysisPatientsRadiotherapyPrivate insurance