2019
Margins in Sinonasal Squamous Cell Carcinoma: Predictors, Outcomes, and the Endoscopic Approach
Torabi SJ, Spock T, Cardoso B, Chao J, Morse E, Manes RP, Judson BL. Margins in Sinonasal Squamous Cell Carcinoma: Predictors, Outcomes, and the Endoscopic Approach. The Laryngoscope 2019, 130: e388-e396. PMID: 31755988, DOI: 10.1002/lary.28315.Peer-Reviewed Original ResearchConceptsSinonasal squamous cell carcinomaHigh-volume facilitiesNational Cancer DatabaseSquamous cell carcinomaPositive marginsOverall survivalSurgical approachMargin statusCell carcinomaEthmoid sinusEndoscopic approachMultivariable binary logistic regressionDecreased overall survivalHigher T stageBinary logistic regressionAdditional therapySelect patientsAdult patientsEndoscopic treatmentMultivariable analysisSurgical managementT stageTherapy administrationDifferentiated tumorsOpen surgeryPrognostic Case Volume Thresholds in Patients With Head and Neck Squamous Cell Carcinoma
Torabi SJ, Benchetrit L, Yu P, Cheraghlou S, Savoca EL, Tate JP, Judson BL. Prognostic Case Volume Thresholds in Patients With Head and Neck Squamous Cell Carcinoma. JAMA Otolaryngology - Head & Neck Surgery 2019, 145: 708-715. PMID: 31194229, PMCID: PMC6567848, DOI: 10.1001/jamaoto.2019.1187.Peer-Reviewed Original ResearchLow-volume facilitiesHigh-volume facilitiesNeck squamous cell carcinomaFacility case volumeSquamous cell carcinomaCase volumeCell carcinomaHNSCC casesStage cancerUS National Cancer DatabaseMultivariable Cox regressionNational Cancer DatabaseImportant prognostic indicatorAdvanced-stage cancerCause mortality outcomesTreatment of HNSCCModerate-volume groupEligible patientsPrognostic meaningAdult patientsAnatomic subsiteCox regressionMean ageMortality outcomesPrognostic indicatorGender disparities in head and neck cancer chemotherapy clinical trials participation and treatment
Benchetrit L, Torabi SJ, Tate JP, Mehra S, Osborn HA, Young MR, Burtness B, Judson BL. Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment. Oral Oncology 2019, 94: 32-40. PMID: 31178210, DOI: 10.1016/j.oraloncology.2019.05.009.Peer-Reviewed Original ResearchConceptsChemotherapy clinical trialsNational Cancer DatabaseClinical trialsDefinitive radiotherapyChemotherapy administrationNational Comprehensive Cancer Network guidelinesMultivariable logistic regression analysisNeck squamous cell carcinomaEnd Results ProgramSquamous cell carcinomaClinical trial participationLogistic regression analysisGeneral U.S. populationChemotherapy useDefinitive chemoradiotherapyNCCN guidelinesAdult patientsDefinitive treatmentMultivariable analysisNetwork guidelinesResults ProgramCell carcinomaTrial participationCancer DatabaseU.S. patientsNonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery
Torabi SJ, Cheraghlou S, Kasle DA, Savoca EL, Judson BL. Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery. The Laryngoscope 2019, 129: 2496-2505. PMID: 30632157, DOI: 10.1002/lary.27785.Peer-Reviewed Original ResearchConceptsEffect of surgeryNon-SCC patientsNeuroendocrine tumorsLaryngeal cancerClinical profileMinor salivary gland tumorsClinical M stageNon-SCC cohortSpecific surgical methodsNational Cancer DatabaseMajority of patientsMajor histological subtypesSalivary gland tumorsAdult patientsImproved survivalTreatment regimenDistant metastasisWorse prognosisHistological subtypesCancer DatabaseLaryngeal carcinomaSurgical methodsRetrospective analysisGland tumorsSurgery
2018
Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014
Cheraghlou S, Schettino A, Zogg CK, Judson BL. Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014. The Laryngoscope 2018, 128: 2762-2769. PMID: 30194691, DOI: 10.1002/lary.27315.Peer-Reviewed Original ResearchConceptsOral cavity cancerLate-stage diseaseAdjuvant therapyOral cancerEnd Results 9 registriesCox survival regressionHigher nodal yieldsNational Cancer DatabaseEarly-stage diseaseKaplan-Meier analysisRetrospective database analysisAnalysis of survivalAdjuvant chemoradiotherapyNodal yieldAdult patientsNeck dissectionRetrospective studyCancer DatabasePrognosisPatientsCancerDiseaseDatabase analysisSurvival regressionChemoradiotherapy
2017
Untreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal
Cheraghlou S, Kuo P, Mehra S, Yarbrough WG, Judson BL. Untreated oral cavity cancer: Long‐term survival and factors associated with treatment refusal. The Laryngoscope 2017, 128: 664-669. PMID: 28865100, DOI: 10.1002/lary.26809.Peer-Reviewed Original ResearchConceptsOral cavity cancerNatural courseTreatment refusalUnivariate Kaplan-Meier analysisFive-year survival rateFacility case volumeNational Cancer DatabaseStage 4 patientsExtent of diseaseMultivariate Cox regressionEarly-stage patientsKaplan-Meier analysisNumber of patientsCommon malignant diseaseLong-term survivalInitial treatment planningAdvanced diseaseUntreated patientsAdult patientsRetrospective reviewCox regressionPatient's likelihoodPoor prognosisInsurance statusMalignant disease
2016
Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer
Cheraghlou S, Kuo P, Judson BL. Treatment delay and facility case volume are associated with survival in early‐stage glottic cancer. The Laryngoscope 2016, 127: 616-622. PMID: 27653749, DOI: 10.1002/lary.26259.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCohort StudiesCombined Modality TherapyDisease-Free SurvivalEarly Detection of CancerFemaleGlottisHospitals, High-VolumeHumansKaplan-Meier EstimateLaryngeal NeoplasmsLaryngectomyMaleMiddle AgedOrgan Sparing TreatmentsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTime FactorsWaiting ListsConceptsEarly-stage glottic cancerGlottic cancerUnivariate Kaplan-Meier analysisSystem factorsFacility case volumeNational Cancer DatabaseMultivariate Cox regressionEarly glottic cancerKaplan-Meier analysisImprovement of outcomesTumor factorsAdult patientsWorse survivalImproved survivalNumber of treatmentsRetrospective studyTreatment delayCox regressionCancer DatabaseCase volumeGovernment insurancePatientsCancerTreatment factorsSurvival variablesTreatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base
Kuo P, Sosa JA, Burtness BA, Husain ZA, Mehra S, Roman SA, Yarbrough WG, Judson BL. Treatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base. Cancer 2016, 122: 1853-1860. PMID: 27019213, DOI: 10.1002/cncr.29962.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapy, AdjuvantDatabases, FactualFemaleHead and Neck NeoplasmsHumansHypopharyngeal NeoplasmsKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsRadiotherapy, AdjuvantSquamous Cell Carcinoma of Head and NeckUnited StatesYoung AdultConceptsHypopharyngeal cancerDefinitive settingTreatment modalitiesSurvival rateNational Cancer Data BaseMultivariate Cox regression analysisKaplan-Meier survival curvesPrimary hypopharyngeal cancerUse of chemotherapyCox regression analysisDefinitive chemoradiotherapyAdjuvant chemoradiotherapyAdjuvant treatmentDefinitive radiotherapyAdult patientsOverall survivalClinical factorsDefinitive treatmentImproved survivalDistant metastasisSurvival outcomesChemoradiotherapyRadiotherapySurvival analysisSurvival curves
2015
Predictors of Survival in Sinonasal Adenocarcinoma
Chen MM, Roman SA, Sosa JA, Judson BL. Predictors of Survival in Sinonasal Adenocarcinoma. Journal Of Neurological Surgery Part B Skull Base 2015, 76: 208-213. PMID: 26225303, PMCID: PMC4433397, DOI: 10.1055/s-0034-1543995.Peer-Reviewed Original ResearchDisease-specific survivalSinonasal adenocarcinomaAdjuvant radiationEnd Results (SEER) databasePredictors of survivalIntestinal-type histologyParanasal sinus involvementMain outcome measuresNonintestinal typeAdult patientsDSS ratesPostoperative radiationFavorable prognosisRetrospective reviewSinus involvementSurveillance EpidemiologyResults databaseType histologyBlack raceOutcome measuresAdenocarcinomaSurgeryPatientsHigh gradePrognosis
2014
Hypopharyngeal cancer incidence, treatment, and survival: Temporal trends in the United States
Kuo P, Chen MM, Decker RH, Yarbrough WG, Judson BL. Hypopharyngeal cancer incidence, treatment, and survival: Temporal trends in the United States. The Laryngoscope 2014, 124: 2064-2069. PMID: 25295351, DOI: 10.1002/lary.24651.Peer-Reviewed Original ResearchConceptsAverage annual percent changeHypopharyngeal cancerPatient demographicsTreatment modalitiesDisease severityEnd Results (SEER) databaseRetrospective cohort studyKaplan-Meier analysisAnnual percent changeAdult patientsCohort studyOverall survivalWorse survivalImproved survivalResults databaseT stageTumor characteristicsCox regressionCancer incidenceMultivariate analysisPercent changeLaryngopharyngectomyCancerIncidenceTemporal trendsSafety of Adult Tonsillectomy: A Population-Level Analysis of 5968 Patients
Chen MM, Roman SA, Sosa JA, Judson BL. Safety of Adult Tonsillectomy: A Population-Level Analysis of 5968 Patients. JAMA Otolaryngology - Head & Neck Surgery 2014, 140: 197-202. PMID: 24481159, DOI: 10.1001/jamaoto.2013.6215.Peer-Reviewed Original ResearchConceptsAdult tonsillectomyPostoperative complicationsReoperation rateSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramSuperficial site infectionRetrospective cohort studyIndependent risk factorUrinary tract infectionSmall case seriesMultivariate logistic regressionOutcomes of interestPopulation-level analysisQuality Improvement ProgramFirst population-level analysisChronic tonsillitisAdult patientsCohort studyCommon complicationComplication rateMost patientsPostoperative periodTract infectionsSite infectionPrognostic factors for squamous cell cancer of the parotid gland: An analysis of 2104 patients
Chen MM, Roman SA, Sosa JA, Judson BL. Prognostic factors for squamous cell cancer of the parotid gland: An analysis of 2104 patients. Head & Neck 2014, 37: 1-7. PMID: 24339135, DOI: 10.1002/hed.23566.Peer-Reviewed Original ResearchConceptsSquamous cell cancerCell cancerRadiation therapyCutaneous squamous cell cancerCommon parotid malignancyAdjuvant radiation therapyDisease-specific mortalityDisease-specific survivalEnd Results (SEER) databaseYears of ageExtraparenchymal extensionCervical metastasisParotid malignanciesAdult patientsPrimary malignancyImproved survivalPrognostic factorsDistant metastasisResults databasePoor prognosisTumor sizeTreatment outcomesParotid glandPatientsSurgery
2013
Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery
Chen MM, Roman SA, Sosa JA, Judson BL. Postdischarge Complications Predict Reoperation and Mortality after Otolaryngologic Surgery. Otolaryngology 2013, 149: 865-872. PMID: 24047818, DOI: 10.1177/0194599813505078.Peer-Reviewed Original ResearchConceptsPostdischarge complicationsOtolaryngologic surgerySurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramProcedure-specific ratesTongue/floorRetrospective cohort studyVenous thromboembolic eventsHigh-risk patientsRisk of reoperationSurgical site infectionOutcomes of interestQuality Improvement ProgramAnesthesiologists classThromboembolic eventsAdult patientsCohort studySite infectionOperative timePostdischarge eventsRisk factorsReoperationAmerican CollegeSurgeryPost‐discharge Complications Predict Reoperation and Mortality after Otolaryngology Surgery
Chen M, Roman S, Sosa J, Judson B. Post‐discharge Complications Predict Reoperation and Mortality after Otolaryngology Surgery. Otolaryngology 2013, 149: p51-p51. DOI: 10.1177/0194599813495815a56.Peer-Reviewed Original ResearchPost-discharge complicationsOtolaryngology surgeryComplication rateMultivariate analysisProcedure-specific ratesTongue/floorRetrospective cohort studyVenous thromboembolic eventsACS-NSQIP databaseHigh-risk patientsRisk of reoperationSurgical site infectionLonger operative timeMultivariate logistic regressionPost-discharge eventsOutcomes of interestT-testChi-square testStudent's t-testAnesthesiologists classUnplanned reoperationHospital stayPostoperative complicationsThromboembolic eventsAdult patients