1991
Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity
Shi W, Bunney B. Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Research 1991, 543: 315-321. PMID: 1676331, DOI: 10.1016/0006-8993(91)90043-u.Peer-Reviewed Original ResearchConceptsDA cellsCell activityFiring rateDA cell activityInteraction of neurotensinGlutamate-induced excitationEffects of neurotensinMidbrain dopamine cell activityDopamine cell activityMidbrain dopamine neuronsSpecific D2 agonistMicroiontophoretic techniquesD2 agonistDopamine neuronsD2 receptorsDopamine effectsSpontaneous activityNeurotensinNT effectsLocal ejectionInhibitionSignificant changesCellsCell levelSame cells
1990
A simple and effective method for preventing the formation of salt bridges between barrels of a multibarrel microiontophoresis electrode
Shi W, Bunney B. A simple and effective method for preventing the formation of salt bridges between barrels of a multibarrel microiontophoresis electrode. Journal Of Neuroscience Methods 1990, 35: 89-91. PMID: 2277537, DOI: 10.1016/0165-0270(90)90098-z.Peer-Reviewed Original Research
1989
Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-33. PMID: 2564893.Peer-Reviewed Original ResearchConceptsRat medial prefrontal cortexMedial prefrontal cortexGamma-aminobutyric acidD2-selective agonistsSelective agonistPrefrontal cortexPFC neuronsInhibitory effectSelective antagonistExtracellular single-unit recordingsD1-selective agonistsSingle-unit recordingsD1-selective antagonistD2-selective antagonistWeak antagonist activityMicroiontophoretic studyMicroiontophoretic techniquesSuperficial laminaeIontophoretic applicationLY171555Pharmacological characterizationInhibitory responsesMajority of cellsPharmacological characteristicsPharmacological profile
1985
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
Clark D, Engberg G, Pileblad E, Svensson T, Carlsson A, Freeman A, Bunney B. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system. Naunyn-Schmiedeberg's Archives Of Pharmacology 1985, 329: 344-354. PMID: 4033804, DOI: 10.1007/bf00496366.Peer-Reviewed Original ResearchConceptsPostsynaptic DA receptorsInhibitory actionDA autoreceptorsDA receptorsNeuronal activityDA cell firing rateExtracellular single-unit recordingsCaudate neuronal activityDA neuronal activityGallamine-paralyzed ratsNigrostriatal DA systemNigrostriatal dopamine systemSingle-unit recordingsCell firing rateReticulata neuronsDA agonistsDA cellsIntravenous administrationMajority of cellsDopamine systemN-propylpiperidineUnit recordingsPartial agonistCell activityFiring rate
1984
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: single spike firing. Journal Of Neuroscience 1984, 4: 2866-2876. PMID: 6150070, PMCID: PMC6564731, DOI: 10.1523/jneurosci.04-11-02866.1984.Peer-Reviewed Original ResearchConceptsSingle-spike firingDA cellsSlow depolarizationCalcium chelator EGTADopamine neuronsSpike firingCalcium-activated potassium conductanceActive DA cellsNigral dopamine neuronsChelator EGTAVivo intracellular recordingsDA neuronsDepolarization inactivationMembrane potentialIontophoretic applicationTrain of spikesIntracellular recordingsExcitatory substancesIntracellular injectionCalcium entryAction potentialsAfterhyperpolarizationPotassium conductanceRate of riseNeuronsThe control of firing pattern in nigral dopamine neurons: burst firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: burst firing. Journal Of Neuroscience 1984, 4: 2877-2890. PMID: 6150071, PMCID: PMC6564720, DOI: 10.1523/jneurosci.04-11-02877.1984.Peer-Reviewed Original ResearchConceptsDA cellsIntracellular injectionBase-line firing rateFiring ratePotassium conductanceIntracellular calcium injectionNigral dopamine neuronsStriatal DA releaseVivo intracellular recordingsBurst-firing modeDegree of burstDA releaseDopamine neuronsExtracellular iontophoresisBurst firingIntracellular recordingsCalcium injectionDopamine cellsCalcium influxCalcium involvementBursting patternInjectionCellsConsecutive spikesBlockadeThe effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonists
1978
d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway
Bunney B, Aghajanian G. d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives Of Pharmacology 1978, 304: 255-261. PMID: 714182, DOI: 10.1007/bf00507966.Peer-Reviewed Original ResearchConceptsDA cellsSubstantia nigraFeedback pathwaysCentral dopamine neuronsIntravenous d-amphetamineNon-convulsant dosesPicrotoxin-treated animalsKainic acid injectionRelease of GABAActivity of dopamineNon-lesioned animalsSingle-cell recordingsDA autoreceptorsDendrodendritic synapsesMicroiontophoretic techniquesAfferent terminalsDepressant effectUnlesioned animalsDopamine neuronsGABA antagonistsAnesthetized ratsD-amphetamineCaudate nucleusAcid injectionHigh doses
1977
Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies
Aghajanian G, Bunney B. Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives Of Pharmacology 1977, 297: 1-7. PMID: 193046, DOI: 10.1007/bf00508803.Peer-Reviewed Original ResearchConceptsDA neuronsDepressant effectDA agonist apomorphineWeak depressant actionSingle-cell recording studiesSingle-cell recordingsAgonist apomorphineDA agonistsMicroiontophoretic applicationMicroiontophoretic techniquesSubstantia nigraDepressant actionDopamine neuronsSingle dopamine neuronsPharmacological characterizationCatecholamine receptorsΒ-adrenoreceptorsCell recordingsCatecholamine agonistsRecording studiesNeuronsAutoreceptorsAntagonist trifluoperazineAgonistsSelective responsivenessElectrophysiological studies of dopamine- innervated cells in the frontal cortex.
Bunney B, Aghajanian G. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances In Biochemical Psychopharmacology 1977, 16: 65-70. PMID: 329653.Peer-Reviewed Original Research