Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons
Chiodo L, Bunney B. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. Journal Of Neuroscience 1985, 5: 2539-2544. PMID: 2863337, PMCID: PMC6565310, DOI: 10.1523/jneurosci.05-09-02539.1985.Peer-Reviewed Original ResearchConceptsDA neuronsClozapine administrationChronic treatmentDepolarization inactivationExtracellular single cell recording techniquesInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidVentral tegmental area (VTA) dopamineSingle cell recording techniquesA10 DA neuronsVivo spontaneous activityMidbrain DA neuronsChloral hydrate anesthesiaCombination of drugsMidbrain dopamine neuronsGamma-aminobutyric acidDifferential effectsMechanism of actionAcute treatmentMicroiontophoretic applicationSubstantia nigraReceptor antagonistDA cellsDopamine neuronsSpontaneous activity