1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatum
1987
Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide
Chiodo L, Freeman A, Bunney B. Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide. Brain Research 1987, 410: 205-211. PMID: 3036308, DOI: 10.1016/0006-8993(87)90317-9.Peer-Reviewed Original ResearchConceptsExcitatory effectsInhibitory effectA9 DA neuronsCCK receptor blockadeSelective CCK antagonistsMidbrain dopamine cellsPrefrontal cortical neuronsInhibitory potencyDA neuronsReceptor blockadeChronic treatmentSensorimotor cortexC-terminal octapeptideCCK antagonistsDA cellsSubstance PAPO effectsCortical neuronsDopamine cellsIntravenous administrationSelective antagonistRat CNSProglumideElectrophysiological studiesCholecystokinin
1984
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHaloperidolIontophoresisMaleMesencephalonPhenazocinePhencyclidineRatsRats, Inbred StrainsReceptors, DopamineReceptors, NeurotransmitterReceptors, PhencyclidineStereoisomerismConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs