1992
Clozapine: A Hypothesised Mechanism for its Unique Clinical Profile
Bunney B. Clozapine: A Hypothesised Mechanism for its Unique Clinical Profile. The British Journal Of Psychiatry. Supplement 1992, 160: 17-21. PMID: 1418885, DOI: 10.1192/s0007125000296864.Peer-Reviewed Original Research
1987
Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?
Freeman A, Bunney B. Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects? Psychopharmacology Series 1987, 3: 225-235. PMID: 2881290, DOI: 10.1007/978-3-642-71288-3_26.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntipsychotic AgentsDopamineDrug Evaluation, PreclinicalHumansPsychotic DisordersRatsSubstantia NigraTegmentum MesencephaliTime FactorsConceptsMost psychotic patientsDA receptor blockerTreatment of choiceDopamine neuron activityCentral catecholamine systemsReceptor blockadeReceptor blockersCatecholamine neuronsNeuroleptic effectsMajor symptomsAntipsychotic drugsCatecholamine systemsAntipsychotic propertiesForebrain regionsNeuronal activityCatecholamine receptorsSide effectsDopamine systemNeuron activityPsychotic patientsTherapeutic efficacyMode of actionFeedback pathwaysTreatmentNeuroleptics