1993
Depolarization inactivation of dopamine neurons: Terminal release characteristics
Moghaddam B, Bunney B. Depolarization inactivation of dopamine neurons: Terminal release characteristics. Synapse 1993, 14: 195-200. PMID: 8105547, DOI: 10.1002/syn.890140302.Peer-Reviewed Original ResearchConceptsExtracellular dopamine levelsChronic haloperidol treatmentDopamine levelsHaloperidol treatmentExtracellular levelsPerfusion of tetrodotoxinExcitatory amino acidsStriatal extracellular levelsVehicle-treated animalsExtracellular glutamate levelsHaloperidol-treated animalsMedial forebrain bundleStriatal dopamine systemGroups of animalsExogenous antagonistsChronic haloperidolChronic treatmentDepolarization inactivationExcitatory actionBasal outflowDopamine neuronsGlutamate levelsImpulse flowForebrain bundleMicrodialysis technique
1990
Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies
Moghaddam B, Gruen R, Roth R, Bunney B, Adams R. Effect ofl-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies. Brain Research 1990, 518: 55-60. PMID: 1975217, DOI: 10.1016/0006-8993(90)90953-9.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistVivo voltammetryExtracellular DA concentrationsMM GluDA outflowStriatal dopamineReceptor antagonistExtracellular dopamineRat striatumVivo dialysisMicrodialysis probeLocal applicationBasal levelsExtracellular concentrationPathophysiological conditionsVivo releaseDA concentrationDopamineL-glutamateField potentialsIonic changesSignificant increaseSelective microelectrodesDepressionStriatumCharacterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexRat medial prefrontal cortexPrefrontal cortexCortical dopamineDopamine releaseChloral hydrate-anesthetized ratsBeta-carboline FG 7142Dopamine release processBasal releasePara-tyrosineVivo microdialysisDopamine levelsFG 7142Local perfusionExtracellular dopamineAlpha-methylExtracellular levelsFmol/StriatumPharmacological manipulationCortexBasal levelsMicrodialysisStimulation conditionsDopamine
1984
The control of firing pattern in nigral dopamine neurons: burst firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: burst firing. Journal Of Neuroscience 1984, 4: 2877-2890. PMID: 6150071, PMCID: PMC6564720, DOI: 10.1523/jneurosci.04-11-02877.1984.Peer-Reviewed Original ResearchConceptsDA cellsIntracellular injectionBase-line firing rateFiring ratePotassium conductanceIntracellular calcium injectionNigral dopamine neuronsStriatal DA releaseVivo intracellular recordingsBurst-firing modeDegree of burstDA releaseDopamine neuronsExtracellular iontophoresisBurst firingIntracellular recordingsCalcium injectionDopamine cellsCalcium influxCalcium involvementBursting patternInjectionCellsConsecutive spikesBlockade