1991
Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance
Shepard P, Bunney B. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca2+-activated K+ conductance. Experimental Brain Research 1991, 86: 141-150. PMID: 1756785, DOI: 10.1007/bf00231048.Peer-Reviewed Original ResearchConceptsAction potentialsPutative dopamine-containing neuronsEffects of apaminDopamine-containing neuronsIntracellular recording techniquesPost-spike afterhyperpolarizationRepetitive firing propertiesTypes of Ca2Apamin-sensitive Ca2Adaptive neuronal responsesZona compactaSubstantia nigraBath applicationInhibitory periodNeuronal responsesAfterhyperpolarizationApaminFiring propertiesRecording techniquesCellular mechanismsElectroresponsive propertiesFrequency adaptationSelective inhibitorInterspike intervalsNeurons
1988
Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine
Silva N, Bunney B. Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine. European Journal Of Pharmacology 1988, 149: 307-315. PMID: 3409955, DOI: 10.1016/0014-2999(88)90661-9.Peer-Reviewed Original ResearchConceptsSensitive neuronsInput resistanceAdministration of DADA-sensitive neuronsSelective D2 antagonistPacemaker-like activityHigh input resistanceZona compactaDA actionD2 antagonistDopamine neuronsIntracellular recordingsFiring rateIntracellular studyNeuronsReversal potentialTissue slicesDopamineHyperpolarizationSulpirideAntagonistCompactaAdministration
1984
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonists
1975
D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons.
Bunney B, Walters J, Kuhar M, Roth R, Aghajanian G. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications 1975, 1: 177-90. PMID: 1223998.Peer-Reviewed Original ResearchConceptsNoradrenergic neuronsDopaminergic neuronsD-amphetamineSingle-unit recording techniquesSubstantia nigra zona compactaSubstantia nigra dopamineLocus coeruleus cellsIsomers of amphetamineCentral dopaminergicZona compactaDA cellsDopamine neuronsLocus coeruleusParalyzed ratsCatecholamine systemsLow dosesInterpretation of studiesPharmacological toolsFiring ratePreferential effectComparative potencyNeuronsAmphetamineLethal dosesRecording techniques
1973
Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones
BUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.Peer-Reviewed Original ResearchConceptsDopamine receptorsAdjacent ventral tegmental areaL-DOPASubstantia nigra zona compactaFiring rateVentral tegmental areaAvailability of dopamineAromatic amino acid decarboxylaseDopamine-containing cellsAmount of dopamineComparison of effectsZona compactaTegmental areaD-amphetamineDopaminergic neuronesAmino acid decarboxylaseReceptor stimulationAcid decarboxylaseDopamineReceptorsApomorphineDrugsStimulationFeedback inhibitionCompacta