1994
Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment
Youngren K, Moghaddam B, Bunney B, Roth R. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neuroscience Letters 1994, 165: 41-44. PMID: 8015734, DOI: 10.1016/0304-3940(94)90704-8.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexChronic treatmentNucleus accumbensPrefrontal cortexChronic clozapine treatmentBasal dopamine releaseExtracellular dopamine levelsChronic clozapineClozapine treatmentIntracerebral microdialysisAcute doseDopaminergic toneDopamine levelsDopamine releaseExtracellular dopamineRat striatumDopamine overflowClozapineBrain regionsPreferential activationStriatumAccumbensCortexTreatmentMicrodialysis
1990
Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum
Moghaddam B, Roth R, Bunney B. Characterization of dopamine release in the rat medial prefrontal cortex as assessed by in vivo microdialysis: Comparison to the striatum. Neuroscience 1990, 36: 669-676. PMID: 2234405, DOI: 10.1016/0306-4522(90)90009-s.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexRat medial prefrontal cortexPrefrontal cortexCortical dopamineDopamine releaseChloral hydrate-anesthetized ratsBeta-carboline FG 7142Dopamine release processBasal releasePara-tyrosineVivo microdialysisDopamine levelsFG 7142Local perfusionExtracellular dopamineAlpha-methylExtracellular levelsFmol/StriatumPharmacological manipulationCortexBasal levelsMicrodialysisStimulation conditionsDopamineUtilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs
Moghaddam B, Bunney B. Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: s51-s57. PMID: 2097674, DOI: 10.1016/0278-5846(90)90086-v.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsDopamine systemNigrostriatal dopamine systemEffects of clozapineRelease of dopamineRat. 2Mesocortical dopamine systemAcute administrationVivo microdialysisMesotelencephalic systemNucleus accumbensPrefrontal effectPrefrontal cortexClozapineExtracellular concentrationDopamineHaloperidolMicrodialysisDrugsSulpirideMesolimbicStriatumAccumbensCortex
1989
Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine
Moghaddam B, Bunney B. Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine. Journal Of Neurochemistry 1989, 53: 652-654. PMID: 2568406, DOI: 10.1111/j.1471-4159.1989.tb07383.x.Peer-Reviewed Original ResearchConceptsPharmacological responsivenessNigrostriatal dopamine systemExtracellular dopamine levelsExtracellular fluidBasal outflowBasal releaseStriatal dopamineHigh calcium levelsVivo microdialysisIonic compositionDopamine levelsCalcium levelsDopamine systemPharmacological manipulationRinger's solutionPerfusionDopamineResponsivenessSolution altersAltersMicrodialysis