1986
Does the cholecystokinin antagonist proglumide possess antipsychotic activity?
Innis R, Bunney B, Charney D, Price L, Glazer W, Sternberg D, Rubin A, Heninger G. Does the cholecystokinin antagonist proglumide possess antipsychotic activity? Psychiatry Research 1986, 18: 1-7. PMID: 3737785, DOI: 10.1016/0165-1781(86)90056-9.Peer-Reviewed Original ResearchConceptsPsychosis ratingsPlacebo-controlled studyRole of cholecystokininCentral dopaminergic activityCCK receptor antagonistsPathogenesis of schizophreniaMesocortical neuronsNeuroleptic medicationNeurotransmitter statusReceptor antagonistDopaminergic activityAntipsychotic activitySchizophrenic patientsCholecystokininNegative findingsPreclinical researchProglumidePatientsSchizophreniaPotential reasonsMedicationsPathogenesisAntagonistMidbrainNeuropeptides
1984
Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons
Chiodo L, Bannon M, Grace A, Roth R, Bunney B. Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience 1984, 12: 1-16. PMID: 6462443, DOI: 10.1016/0306-4522(84)90133-7.Peer-Reviewed Original ResearchConceptsSpikes/sDopamine neuronsPiriform cortexDopamine levelsCaudate nucleusCingulate cortexIntravenous administrationDopamine cellsFiring rateGlyoxylic acid-induced histofluorescenceCatecholamine histofluorescence techniquesMesocortical dopamine neuronsNerve terminal autoreceptorsNigrostriatal dopamine cellsDose-dependent inhibitory responseDopamine agonist apomorphineBasal discharge rateMidbrain dopaminergic neuronsMidbrain dopaminergic systemMean firing rateMidbrain dopamine systemMesocortical neuronsAgonist apomorphineMicroiontophoretic applicationAntidromic activation