1989
Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-33. PMID: 2564893.Peer-Reviewed Original ResearchConceptsRat medial prefrontal cortexMedial prefrontal cortexGamma-aminobutyric acidD2-selective agonistsSelective agonistPrefrontal cortexPFC neuronsInhibitory effectSelective antagonistExtracellular single-unit recordingsD1-selective agonistsSingle-unit recordingsD1-selective antagonistD2-selective antagonistWeak antagonist activityMicroiontophoretic studyMicroiontophoretic techniquesSuperficial laminaeIontophoretic applicationLY171555Pharmacological characterizationInhibitory responsesMajority of cellsPharmacological characteristicsPharmacological profile
1985
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
Clark D, Engberg G, Pileblad E, Svensson T, Carlsson A, Freeman A, Bunney B. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system. Naunyn-Schmiedeberg's Archives Of Pharmacology 1985, 329: 344-354. PMID: 4033804, DOI: 10.1007/bf00496366.Peer-Reviewed Original ResearchConceptsPostsynaptic DA receptorsInhibitory actionDA autoreceptorsDA receptorsNeuronal activityDA cell firing rateExtracellular single-unit recordingsCaudate neuronal activityDA neuronal activityGallamine-paralyzed ratsNigrostriatal DA systemNigrostriatal dopamine systemSingle-unit recordingsCell firing rateReticulata neuronsDA agonistsDA cellsIntravenous administrationMajority of cellsDopamine systemN-propylpiperidineUnit recordingsPartial agonistCell activityFiring rate