1984
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: single spike firing. Journal Of Neuroscience 1984, 4: 2866-2876. PMID: 6150070, PMCID: PMC6564731, DOI: 10.1523/jneurosci.04-11-02866.1984.Peer-Reviewed Original ResearchConceptsSingle-spike firingDA cellsSlow depolarizationCalcium chelator EGTADopamine neuronsSpike firingCalcium-activated potassium conductanceActive DA cellsNigral dopamine neuronsChelator EGTAVivo intracellular recordingsDA neuronsDepolarization inactivationMembrane potentialIontophoretic applicationTrain of spikesIntracellular recordingsExcitatory substancesIntracellular injectionCalcium entryAction potentialsAfterhyperpolarizationPotassium conductanceRate of riseNeuronsThe control of firing pattern in nigral dopamine neurons: burst firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: burst firing. Journal Of Neuroscience 1984, 4: 2877-2890. PMID: 6150071, PMCID: PMC6564720, DOI: 10.1523/jneurosci.04-11-02877.1984.Peer-Reviewed Original ResearchConceptsDA cellsIntracellular injectionBase-line firing rateFiring ratePotassium conductanceIntracellular calcium injectionNigral dopamine neuronsStriatal DA releaseVivo intracellular recordingsBurst-firing modeDegree of burstDA releaseDopamine neuronsExtracellular iontophoresisBurst firingIntracellular recordingsCalcium injectionDopamine cellsCalcium influxCalcium involvementBursting patternInjectionCellsConsecutive spikesBlockade
1983
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates
Grace A, Bunney B. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates. Neuroscience 1983, 10: 317-331. PMID: 6633864, DOI: 10.1016/0306-4522(83)90136-7.Peer-Reviewed Original ResearchConceptsInitial segment spikesDopamine neuronsSlow depolarizationAction potentialsAxon hillockDendritic dopamine releaseLong-duration afterhyperpolarizationNigral dopamine neuronsLow-threshold spikesLucifer yellow injectionExtracellular recording techniquesLong-duration spikesAction potential generationDopaminergic neuronsSpecific ionic currentsIntracellular recordingsDopamine releaseIntracellular injectionElectrophysiological studiesDendritic spikesMajor dendritesNeuron 2Action potential generating mechanismSomatic regionNeuronal compartments