1978
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.Peer-Reviewed Original ResearchConceptsChronic haloperidol treatmentDA cellsHaloperidol treatmentControl animalsCell activityExtracellular single-unit recordingsDopaminergic cell activityDopaminergic neuronal activityNigral DA cellsNeurological side effectsDopamine cell activitySingle-unit recordingsFeedback pathwaysComparison of effectsDA neuronsTime-dependent mannerMicroiontophoretic techniquesClinical effectsKainic acidAntipsychotic drugsDepolarization blockCaudate nucleusNeuronal activitySide effectsUnit recordings
1973
Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones
BUNNEY B, AGHAJANIAN G, ROTH R. Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones. Nature 1973, 245: 123-125. PMID: 4518113, DOI: 10.1038/newbio245123a0.Peer-Reviewed Original ResearchConceptsDopamine receptorsAdjacent ventral tegmental areaL-DOPASubstantia nigra zona compactaFiring rateVentral tegmental areaAvailability of dopamineAromatic amino acid decarboxylaseDopamine-containing cellsAmount of dopamineComparison of effectsZona compactaTegmental areaD-amphetamineDopaminergic neuronesAmino acid decarboxylaseReceptor stimulationAcid decarboxylaseDopamineReceptorsApomorphineDrugsStimulationFeedback inhibitionCompacta