1993
Depolarization inactivation of dopamine neurons: Terminal release characteristics
Moghaddam B, Bunney B. Depolarization inactivation of dopamine neurons: Terminal release characteristics. Synapse 1993, 14: 195-200. PMID: 8105547, DOI: 10.1002/syn.890140302.Peer-Reviewed Original ResearchConceptsExtracellular dopamine levelsChronic haloperidol treatmentDopamine levelsHaloperidol treatmentExtracellular levelsPerfusion of tetrodotoxinExcitatory amino acidsStriatal extracellular levelsVehicle-treated animalsExtracellular glutamate levelsHaloperidol-treated animalsMedial forebrain bundleStriatal dopamine systemGroups of animalsExogenous antagonistsChronic haloperidolChronic treatmentDepolarization inactivationExcitatory actionBasal outflowDopamine neuronsGlutamate levelsImpulse flowForebrain bundleMicrodialysis technique
1980
Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment
Grace A, Bunney B. Effects of baclofen on nigral dopaminergic cell activity following acute and chronic haloperidol treatment. Brain Research Bulletin 1980, 5: 537-543. DOI: 10.1016/0361-9230(80)90087-8.Peer-Reviewed Original ResearchChronic haloperidol treatmentDopaminergic cell activityEffects of baclofenHaloperidol treatmentLow dosesExtracellular single-unit recording techniquesNeuroleptic-induced side effectsRat nigral dopaminergic neuronsCell activitySingle-unit recording techniquesInhibitory effectNigral DA cellsSingle low dosesNigral dopaminergic neuronsTreatment of spasticityAction of baclofenDose-response curveMechanism of actionDepolarization inactivationDopaminergic neuronsHaloperidol pretreatmentDA cellsPossible efficacyNigral inputsBaclofen
1979
The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat
Skirboll L, Bunney B. The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat. Life Sciences 1979, 25: 1419-1433. PMID: 522610, DOI: 10.1016/0024-3205(79)90420-x.Peer-Reviewed Original ResearchConceptsCaudate nucleusIontophoretic dopamineChronic HAL treatmentChronic haloperidol treatmentDifferent treatment regimensEffects of haloperidolDays of treatmentType IDrug terminationPostsynaptic supersensitivityHaloperidol treatmentTardive dyskinesiaTreatment regimensDaily dosesHAL treatmentSingle doseSpontaneous activitySupersensitive responseTreatment groupsType I unitsHaloperidolType II unitsInhibitory effectDopamineActive type IEFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY
Bunney B, Grace A. EFFECTS OF CHRONIC HALOPERIDOL TREATMENT ON NIGRAL DOPAMINERGIC CELL ACTIVITY. 1979, 666-668. DOI: 10.1016/b978-1-4832-8363-0.50202-0.Peer-Reviewed Original ResearchActive DA cellsChronic haloperidol treatmentDA cellsExtracellular single-unit recording techniquesRat nigral dopaminergic neuronsSingle-unit recording techniquesNigral dopaminergic neuronsNeurological side effectsEffects of chronicDepolarization inactivationHaloperidol treatmentDopaminergic neuronsExcitatory inputsSide effectsCell activityRecording techniquesPossible new mechanismSubsequent studiesTreatmentCellsAnimalsNigralChronicNeurons
1978
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.Peer-Reviewed Original ResearchConceptsChronic haloperidol treatmentDA cellsHaloperidol treatmentControl animalsCell activityExtracellular single-unit recordingsDopaminergic cell activityDopaminergic neuronal activityNigral DA cellsNeurological side effectsDopamine cell activitySingle-unit recordingsFeedback pathwaysComparison of effectsDA neuronsTime-dependent mannerMicroiontophoretic techniquesClinical effectsKainic acidAntipsychotic drugsDepolarization blockCaudate nucleusNeuronal activitySide effectsUnit recordings