Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment
Youngren K, Moghaddam B, Bunney B, Roth R. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neuroscience Letters 1994, 165: 41-44. PMID: 8015734, DOI: 10.1016/0304-3940(94)90704-8.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexChronic treatmentNucleus accumbensPrefrontal cortexChronic clozapine treatmentBasal dopamine releaseExtracellular dopamine levelsChronic clozapineClozapine treatmentIntracerebral microdialysisAcute doseDopaminergic toneDopamine levelsDopamine releaseExtracellular dopamineRat striatumDopamine overflowClozapineBrain regionsPreferential activationStriatumAccumbensCortexTreatmentMicrodialysis