1995
Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease
Price L, Spencer D, Marek K, Robbins R, Leranth C, Farhi A, Naftolin F, Roth R, Bunney B, Hoffer P, Makuch R, Redmond D. Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease. Biological Psychiatry 1995, 38: 498-505. PMID: 8562661, DOI: 10.1016/0006-3223(95)00129-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrain Tissue TransplantationCaudate NucleusDepressive DisorderDopamineFemaleFetal Tissue TransplantationFollow-Up StudiesHumansMaleMesencephalonMiddle AgedNeurocognitive DisordersNeuropsychological TestsPanic DisorderParkinson DiseasePostoperative ComplicationsProspective StudiesConceptsParkinson's diseasePsychiatric statusHuman fetal mesencephalic tissueAdrenal medullary graftsAdrenal medullary transplantationFetal mesencephalic tissueSystematic psychiatric assessmentPerioperative sequelaeMesencephalic tissuePsychiatric sequelaeCaudate nucleusPsychiatric assessmentNeurobiological effectsBehavioral symptomsTissue transplantationDiseasePatientsTransplantationSequelaeSuch episodesEpisodesGroup effectsStatusDeliriumDiscrete episodesGeneral Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease
Sass K, Buchanan C, Westerveld M, Marek K, Farhi A, Robbins R, Naftolin F, Vollmer T, Leranth C, Roth R, Price L, Bunney B, Elsworth J, Hoffer P, Redmond D, Spencer D. General Cognitive Ability Following Unilateral and Bilateral Fetal Ventral Mesencephalic Tissue Transplantation for Treatment of Parkinson's Disease. JAMA Neurology 1995, 52: 680-686. PMID: 7619024, DOI: 10.1001/archneur.1995.00540310050016.Peer-Reviewed Original ResearchConceptsCognitive abilitiesNonverbal cognitive abilityVerbal cognitive abilityInformation-processing speedVerbal memoryNeuropsychological profileTest batteryCognitive functionNormal cognitive functionCognitive dysfunctionRight caudate nucleusCaudate nucleusFactor analysisTissue transplantationParkinson's disease
1993
Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients With Parkinson's Disease
SPENCER D, ROBBINS R, NAFTOLIN F, MAREK K, VOLLMER T, LERANTH C, ROTH R, PRICE L, GJEDDE A, BUNNEY B, SASS K, ELSWORTH J, KIER E, MAKUCH R, HOFFER P, REDMOND D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue Into the Caudate Nucleus of Patients With Parkinson's Disease. Obstetrical & Gynecological Survey 1993, 48: 413-415. DOI: 10.1097/00006254-199306000-00013.Peer-Reviewed Original Research
1992
Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease
Spencer D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B, Sass K, Elsworth J, Kier E, Makuch R, Hoffer P, Redmond D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease. New England Journal Of Medicine 1992, 327: 1541-1548. PMID: 1435880, DOI: 10.1056/nejm199211263272201.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAntiparkinson AgentsCaudate NucleusCryopreservationCyclosporineDopamineFemaleFetal Tissue TransplantationHomovanillic AcidHumansMagnetic Resonance ImagingMaleMesencephalonMiddle AgedMotor ActivityParkinson DiseasePutamenStereotaxic TechniquesTomography, Emission-ComputedConceptsCase patientsParkinson's diseaseMesencephalic tissueCaudate nucleusHuman fetal ventral mesencephalic tissueFetal ventral mesencephalic tissueHuman fetal mesencephalic tissueContinued disease progressionFetal dopaminergic neuronsFetal mesencephalic tissueVentral mesencephalic tissueSevere Parkinson's diseaseOptimal drug therapySigns of parkinsonismMidbrain dopamine neuronsPositron emission tomographyMonths of evaluationAntiparkinsonian medicationUnilateral transplantationDrug holidayMore medicationsStriatonigral degenerationNeurologic functionDopaminergic neuronsDrug therapy
1984
Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons
Chiodo L, Bannon M, Grace A, Roth R, Bunney B. Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience 1984, 12: 1-16. PMID: 6462443, DOI: 10.1016/0306-4522(84)90133-7.Peer-Reviewed Original ResearchConceptsSpikes/sDopamine neuronsPiriform cortexDopamine levelsCaudate nucleusCingulate cortexIntravenous administrationDopamine cellsFiring rateGlyoxylic acid-induced histofluorescenceCatecholamine histofluorescence techniquesMesocortical dopamine neuronsNerve terminal autoreceptorsNigrostriatal dopamine cellsDose-dependent inhibitory responseDopamine agonist apomorphineBasal discharge rateMidbrain dopaminergic neuronsMidbrain dopaminergic systemMean firing rateMidbrain dopamine systemMesocortical neuronsAgonist apomorphineMicroiontophoretic applicationAntidromic activation
1983
Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization
Grace A, Bunney B. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization. Neuroscience 1983, 10: 301-315. PMID: 6633863, DOI: 10.1016/0306-4522(83)90135-5.Peer-Reviewed Original ResearchConceptsAction potentialsDopamine neuronsDopamine cellsGlyoxylic acid-induced catecholamine fluorescenceInput resistanceDopamine synthesizing enzymePostsynaptic target areasIntracellular dopamine contentNigral dopamine cellsPossible modulatory effectDopamine-containing cellsIntracellular dopamine concentrationSame inhibitory effectHigh input resistanceInitial segmentAntidromic activationDopaminergic neuronsDopamine contentIntracellular recordingsDopamine synthesisCaudate nucleusElectrophysiological characteristicsTyrosine hydroxylaseCatecholamine fluorescenceModulatory effects
1979
Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.Peer-Reviewed Original ResearchConceptsDopamine autoIntravenous apomorphineDopamine agonistsPostsynaptic receptorsCentral nervous systemSubstantia nigraDopaminergic cellsDifferential sensitivityDopamine cellsDopaminergic influenceCaudate nucleusLarge dosesCaudate cellsNervous systemActive neuronsBehavioral effectsElectrophysiological evidenceApomorphineAgonistsParadoxical behavioural effectsReceptorsDopamineCellsNeuronsDosesThe effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat
Skirboll L, Bunney B. The effects of acute and chronic haloperidol treatment on spontaneously firing neurons in the caudate nucleus of the rat. Life Sciences 1979, 25: 1419-1433. PMID: 522610, DOI: 10.1016/0024-3205(79)90420-x.Peer-Reviewed Original ResearchConceptsCaudate nucleusIontophoretic dopamineChronic HAL treatmentChronic haloperidol treatmentDifferent treatment regimensEffects of haloperidolDays of treatmentType IDrug terminationPostsynaptic supersensitivityHaloperidol treatmentTardive dyskinesiaTreatment regimensDaily dosesHAL treatmentSingle doseSpontaneous activitySupersensitive responseTreatment groupsType I unitsHaloperidolType II unitsInhibitory effectDopamineActive type I
1978
Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity
Bunney B, Grace A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sciences 1978, 23: 1715-1727. PMID: 31529, DOI: 10.1016/0024-3205(78)90471-x.Peer-Reviewed Original ResearchConceptsChronic haloperidol treatmentDA cellsHaloperidol treatmentControl animalsCell activityExtracellular single-unit recordingsDopaminergic cell activityDopaminergic neuronal activityNigral DA cellsNeurological side effectsDopamine cell activitySingle-unit recordingsFeedback pathwaysComparison of effectsDA neuronsTime-dependent mannerMicroiontophoretic techniquesClinical effectsKainic acidAntipsychotic drugsDepolarization blockCaudate nucleusNeuronal activitySide effectsUnit recordingsd-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway
Bunney B, Aghajanian G. d-Amphetamine-induced depression of central dopamine neurons: Evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives Of Pharmacology 1978, 304: 255-261. PMID: 714182, DOI: 10.1007/bf00507966.Peer-Reviewed Original ResearchConceptsDA cellsSubstantia nigraFeedback pathwaysCentral dopamine neuronsIntravenous d-amphetamineNon-convulsant dosesPicrotoxin-treated animalsKainic acid injectionRelease of GABAActivity of dopamineNon-lesioned animalsSingle-cell recordingsDA autoreceptorsDendrodendritic synapsesMicroiontophoretic techniquesAfferent terminalsDepressant effectUnlesioned animalsDopamine neuronsGABA antagonistsAnesthetized ratsD-amphetamineCaudate nucleusAcid injectionHigh doses
1973
ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONS
BUNNEY B, AGHAJANIAN G. ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONS. 1973, 957-962. DOI: 10.1016/b978-0-08-017922-3.50182-9.Peer-Reviewed Original ResearchDA synthesisDopaminergic neuronsDA cellsElectrophysiological effectsD-AMPLow ejection currentsTyrosine hydroxylase inhibitorIntra-peritoneal administrationCell firing rateDA neuronsDA receptorsDepressant effectOlfactory tubercleEjection currentsIntravenous administrationCaudate nucleusHydroxylase inhibitorPostsynaptic cellFiring rateMinimal responseNeuronsBlockadeAntipsychotic phenothiazinesAdministrationAmphetamine