Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons
Chiodo L, Bunney B. Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal Of Neuroscience 1983, 3: 1607-1619. PMID: 6135762, PMCID: PMC6564520, DOI: 10.1523/jneurosci.03-08-01607.1983.Peer-Reviewed Original ResearchConceptsExtrapyramidal side effectsDepolarization inactivationA10 neuronsAntipsychotic drugsDA neuronsDopaminergic neuronsSide effectsExtracellular single-unit recording techniquesExcitatory amino acid glutamateInhibitory neurotransmitter gamma-aminobutyric acidSingle-unit recording techniquesNeurotransmitter gamma-aminobutyric acidActive DA cellsA10 dopaminergic neuronsMidbrain dopaminergic neuronsGamma-aminobutyric acidActivity of A9Amino acid glutamateChronic administrationMicroiontophoretic applicationNeuroleptic treatmentNeuroleptic administrationAtypical neurolepticsTricyclic antidepressantsDA cells