1994
5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine
Rasmusson A, Goldstein L, Deutch A, Bunney B, Roth R. 5‐HT1a agonist ±‐ 8‐OH‐DPAT modulates basal and stress‐induced changes in medial prefrontal cortical dopamine. Synapse 1994, 18: 218-224. PMID: 7855734, DOI: 10.1002/syn.890180307.Peer-Reviewed Original ResearchConceptsDopamine utilizationMedial prefrontal cortexStress-induced changesClinical efficacyMedial prefrontal cortical dopamineMicrograms/Prefrontal cortexAnxiety disordersPrefrontal cortical dopamineFootshock-induced increaseObserved clinical efficacyDopamine terminal fieldsCortical dopamineFootshock stressExtracellular dopamineHuman anxiety disordersNucleus accumbensSame doseTerminal fieldsEx vivo brain tissueNeurochemical analysisDopamine systemDPATAgonistsBrain tissue
1990
Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons
Shi W, Bunney B. Neurotensin attenuates dopamine D2 agonist quinpirole-induced inhibition of midbrain dopamine neurons. Neuropharmacology 1990, 29: 1095-1097. PMID: 1982340, DOI: 10.1016/0028-3908(90)90119-c.Peer-Reviewed Original ResearchConceptsD2 agonistDA cellsSingle-unit recording techniquesMidbrain DA neuronsCentral DA systemsDopamine D2 agonistMidbrain dopamine neuronsSpecific D2 agonistDA neuronsIntracerebroventricular administrationDopamine neuronsSpontaneous activityDA systemInhibitory effectRecording techniquesAgonistsNeuronsBiochemical studiesCellsQuinpiroleNeurotensinRatsAdministration
1988
The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.
Bean A, Shepard P, Bunney B, Nestler E, Roth R. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology 1988, 34: 715-8. PMID: 2974120.Peer-Reviewed Original ResearchConceptsPertussis toxin injectionDopamine synthesisToxin injectionDopamine autoreceptorsRat striatumPertussis toxinAutoreceptor-mediated inhibitionDopamine agonist apomorphineG proteinsAgonist apomorphineUnilateral administrationControl ratsSystemic administrationStriatal tissueEffects of activationAutoreceptorsApomorphineStriatumRatsAdministrationInjectionToxinActivationStriataAgonists
1985
Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology
Grace A, Bunney B. Low doses of apomorphine elicit two opposing influences on dopamine cell electrophysiology. Brain Research 1985, 333: 285-298. PMID: 3995296, DOI: 10.1016/0006-8993(85)91582-3.Peer-Reviewed Original ResearchConceptsDA cell firingDA cellsLow dosesInput resistanceDA agonistsReversal potentialStriatonigral pathwayCell firingCell firing rateElectrophysiological actionsApomorphine effectApomorphine administrationSlow depolarizationIntracellular recordingsIntravenous administrationDopamine cellsInhibitory inputsApomorphineStriatal cellsAction potentialsFiring rateAgonistsDosesCell dischargeCell electrophysiology
1980
Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons
Grace A, Hommer D, Bunney B. Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons. Brain Research Bulletin 1980, 5: 105-109. DOI: 10.1016/0361-9230(80)90017-9.Peer-Reviewed Original ResearchDA cellsZona reticulataGABA agonistsInhibitory influenceDA cell firing rateDopamine receptor blocker haloperidolStriato-nigral pathwayNigral dopamine cellsCell firing rateReticulata neuronsStriatal influencesSubstantia nigraDopaminergic cellsDopamine cellsNoxious stimuliLow dosesFiring rateNeuronsInhibitory effectAgonistsCell rateCellsHaloperidolMuscimolDoses
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonistsDopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists
Skirboll L, Grace A, Bunney B. Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists. Science 1979, 206: 80-82. PMID: 482929, DOI: 10.1126/science.482929.Peer-Reviewed Original ResearchConceptsDopamine autoIntravenous apomorphineDopamine agonistsPostsynaptic receptorsCentral nervous systemSubstantia nigraDopaminergic cellsDifferential sensitivityDopamine cellsDopaminergic influenceCaudate nucleusLarge dosesCaudate cellsNervous systemActive neuronsBehavioral effectsElectrophysiological evidenceApomorphineAgonistsParadoxical behavioural effectsReceptorsDopamineCellsNeuronsDoses
1977
Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies
Aghajanian G, Bunney B. Dopamine “Autoreceptors”: Pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives Of Pharmacology 1977, 297: 1-7. PMID: 193046, DOI: 10.1007/bf00508803.Peer-Reviewed Original ResearchConceptsDA neuronsDepressant effectDA agonist apomorphineWeak depressant actionSingle-cell recording studiesSingle-cell recordingsAgonist apomorphineDA agonistsMicroiontophoretic applicationMicroiontophoretic techniquesSubstantia nigraDepressant actionDopamine neuronsSingle dopamine neuronsPharmacological characterizationCatecholamine receptorsΒ-adrenoreceptorsCell recordingsCatecholamine agonistsRecording studiesNeuronsAutoreceptorsAntagonist trifluoperazineAgonistsSelective responsiveness