1996
Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons
Shim S, Bunney B, Shi W. Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons. Neuropsychopharmacology 1996, 15: 437-441. PMID: 8914116, DOI: 10.1016/s0893-133x(96)00052-8.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDA neuronsPrefrontal cortexSubstantia nigraPFC lesionsBursting activityFiring rateActive DA cellsSN DA neuronsActive DA neuronsMidbrain dopamine neuronsSingle-unit recordingsMedial prefrontal cortexDA cellsDopamine neuronsTegmental areaLocal injectionIbotenic acidUnit recordingsLesionsSame lesionNeuronsRatsActivityCortex
1989
The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons
Esposito E, Bunney B. The effect of acute and chronic treatment with SCH 23390 on the spontaneous activity of midbrain dopamine neurons. European Journal Of Pharmacology 1989, 162: 109-113. PMID: 2656273, DOI: 10.1016/0014-2999(89)90609-2.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaVentral tegmental areaActive DA neuronsSCH 23390Chronic treatmentDA neuronsDopamine neuronsDepolarization blockSpontaneous activityDA receptor blockadeAcute subcutaneous injectionGroups of ratsMidbrain dopamine neuronsChronic haloperidolReceptor blockadeChronic administrationPars compactaTegmental areaAntipsychotic drugsSubcutaneous injectionChronic experimentsMarked reductionNeuronsTreatmentHaloperidol
1987
Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences
Chiodo L, Bunney B. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences. Journal Of Neuroscience 1987, 7: 629-633. PMID: 2881987, PMCID: PMC6569064, DOI: 10.1523/jneurosci.07-03-00629.1987.Peer-Reviewed Original ResearchConceptsDepolarization-induced inactivationFiring rateDopaminergic neuronsDopamine receptor agonist apomorphineMonths' continuous treatmentAcute oral administrationBasal firing rateActive DA neuronsReceptor agonist apomorphineA10 dopaminergic neuronsActive dopamine neuronsClassical antipsychotic drugsDopamine-containing neuronsPresence of haloperidolHr of administrationLong-term treatmentMidbrain dopaminergic neuronsCholecystokinin receptor antagonistAge-matched controlsHaloperidol resultsA10 regionDA neuronsAcute administrationAgonist apomorphineNeuroleptic haloperidol