2019
Regional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus
Njei B, Esserman D, Krishnan S, Ohl M, Tate JP, Hauser RG, Taddei T, Lim J, Justice AC. Regional and Rural-Urban Differences in the Use of Direct-acting Antiviral Agents for Hepatitis C Virus. Medical Care 2019, 57: 279-285. PMID: 30807449, PMCID: PMC6436819, DOI: 10.1097/mlr.0000000000001071.Peer-Reviewed Original ResearchConceptsDirect-acting antiviral agentsHepatitis C virus infectionVeterans Affairs Healthcare SystemRural-Urban Commuting Area codesCurative HCV treatmentRural-urban designationC virus infectionElectronic health record dataHepatitis C virusPrior treatment experienceLower odds ratioHealth record dataZone improvement plan codeEligible patientsHCV treatmentAntiretroviral medicationsRural-urban residenceLiver diseaseUnadjusted analysesC virusRural-urban differencesOdds ratioMultivariable modelLower incidenceObservational studyImpact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014
Sharma P, McCarty TR, Yadav S, Ngu JN, Njei B. Impact of Bariatric Surgery on Outcomes of Patients with Sickle Cell Disease: a Nationwide Inpatient Sample Analysis, 2004–2014. Obesity Surgery 2019, 29: 1789-1796. PMID: 30805858, DOI: 10.1007/s11695-019-03780-0.Peer-Reviewed Original ResearchConceptsSickle cell diseaseVaso-occlusive crisisAcute chest syndromeBariatric surgeryIncidence risk ratioChest syndromeMorbid obesityClinical outcomesHospitalization costsCell diseaseUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseOutcomes of patientsMulti-organ failureSurgery-related complicationsHigher hospitalization costsUrinary tract infectionWeight loss surgeryDisease-specific treatmentLength of staySickle cell patientsHospital mortalityRespiratory failureThromboembolic eventsConclusionsBariatric surgeryEffects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis
Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH, Group V. Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 2019, 156: 1693-1706.e12. PMID: 30660733, DOI: 10.1053/j.gastro.2019.01.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularCholesterolFemaleHeart FailureHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLiver CirrhosisLiver NeoplasmsMaleMiddle AgedMyocardial InfarctionPropensity ScoreProportional Hazards ModelsRandomized Controlled Trials as TopicRetrospective StudiesStrokeSurvival RateUnited StatesConceptsRetrospective cohort studyStatin exposureLarge national cohortHepatic decompensationStatin useCohort studyHazard ratioNational cohortMultivariable Cox proportional hazards modelsCox proportional hazards modelBaseline total cholesterolPrior statin exposureStatin-naïve subjectsEffect of hypercholesterolemiaVeterans Health AdministrationProportional hazards modelHepatocellular carcinoma developmentDecrease of mortalityRisk-set matchingChild-TurcottePugh classStatin therapyDL increaseTotal cholesterolHepatic functionNational Trends in Use of Opioid Drugs Among Cirrhosis-related Hospitalizations in the United States, 2004 to 2012
McCarty TR, Haque L, Njei B. National Trends in Use of Opioid Drugs Among Cirrhosis-related Hospitalizations in the United States, 2004 to 2012. Journal Of Clinical Gastroenterology 2019, 53: 78-79. PMID: 27984400, DOI: 10.1097/mcg.0000000000000771.Peer-Reviewed Original Research
2018
Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Njei B, Sharma P, McCarty TR, Singh M, Haque L, Aslanian HR, Jamidar P, Muniraj T. Cannabis Use Is Associated With Increased Risk of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Pancreas 2018, 47: 1142-1149. PMID: 30134357, DOI: 10.1097/mpa.0000000000001143.Peer-Reviewed Original ResearchConceptsPost-endoscopic retrograde cholangiopancreatography pancreatitisIncidence risk ratioCholangiopancreatography pancreatitisCannabis useRisk of PEPEndoscopic retrograde cholangiopancreatography pancreatitisUS Nationwide Inpatient SampleRate of PEPShorter hospital stayNationwide Inpatient SampleNinth Edition codesImpact of cannabisPoisson regression modelsHospital deathHospital stayIndependent predictorsEdition codesRisk ratioInpatient SampleInternational ClassificationMultivariate analysisPancreatitisPatientsCannabisSignificant increaseImpact of bariatric surgery in patients with HIV infection
Sharma P, McCarty TR, Ngu JN, O'Donnell M, Njei B. Impact of bariatric surgery in patients with HIV infection. AIDS 2018, 32: 1959-1965. PMID: 30157083, PMCID: PMC6126912, DOI: 10.1097/qad.0000000000001915.Peer-Reviewed Original ResearchConceptsBariatric surgeryIncidence risk ratioMorbid obesityRespiratory failureObese patientsRenal failureClinical outcomesUnited States Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseObese HIV patientsLife-threatening morbidityUrinary tract infectionWeight loss surgeryRelevant clinical outcomesLength of stayRates of obesityHospital mortalityHIV patientsThromboembolic eventsSecondary outcomesTract infectionsHIV infectionPrimary outcomeMultivariable analysisDischarge diagnosis
2017
Impact of Bariatric Surgery on Outcomes of Patients with Inflammatory Bowel Disease: a Nationwide Inpatient Sample Analysis, 2004–2014
Sharma P, McCarty TR, Njei B. Impact of Bariatric Surgery on Outcomes of Patients with Inflammatory Bowel Disease: a Nationwide Inpatient Sample Analysis, 2004–2014. Obesity Surgery 2017, 28: 1015-1024. PMID: 29047047, DOI: 10.1007/s11695-017-2959-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBariatric SurgeryDatabases, FactualFemaleHospital CostsHospital MortalityHospitalizationHumansIncidenceInflammatory Bowel DiseasesInpatientsMaleMiddle AgedMorbidityObesity, MorbidPostoperative ComplicationsPrognosisTreatment OutcomeUnited StatesYoung AdultConceptsInflammatory bowel diseaseIncidence risk ratioObese IBD patientsBariatric surgeryMorbid obesityIBD patientsRenal failureBowel diseaseClinical outcomesUnited States National Inpatient Sample (NIS) databaseNational Inpatient Sample databaseOutcomes of patientsLength of stayPaucity of dataHospital mortalityThromboembolic eventsObese patientsSecondary outcomesHospitalized patientsPrimary outcomeMultivariable analysisDischarge diagnosisFistula formationHospitalization costsRisk ratioImpact of bariatric surgery on outcomes of patients with nonalcoholic fatty liver disease: a nationwide inpatient sample analysis, 2004–2012
McCarty TR, Echouffo-Tcheugui JB, Lange A, Haque L, Njei B. Impact of bariatric surgery on outcomes of patients with nonalcoholic fatty liver disease: a nationwide inpatient sample analysis, 2004–2012. Surgery For Obesity And Related Diseases 2017, 14: 74-80. PMID: 29055669, DOI: 10.1016/j.soard.2017.09.511.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseasePrior bariatric surgeryBariatric surgeryFatty liver diseaseIncidence risk ratioNAFLD patientsMorbid obesityRenal failureClinical outcomesLiver diseaseMyocardial infarctionRisk ratioNationwide Inpatient Sample AnalysisNationwide Inpatient Sample databaseObese NAFLD patientsOutcomes of patientsBariatric surgery proceduresMorbidly obese individualsPopulation-based dataHospital mortalityHospital morbidityInpatient mortalitySecondary outcomesHospitalized patientsPrimary outcomePursuing a Gastroenterology Fellowship as a Foreign Medical Graduate
Njei B, Taddei TH. Pursuing a Gastroenterology Fellowship as a Foreign Medical Graduate. Digestive Diseases And Sciences 2017, 62: 1852-1854. PMID: 28555326, DOI: 10.1007/s10620-017-4624-9.Commentaries, Editorials and LettersEarly transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding
Njei B, McCarty TR, Laine L. Early transjugular intrahepatic portosystemic shunt in US patients hospitalized with acute esophageal variceal bleeding. Journal Of Gastroenterology And Hepatology 2017, 32: 852-858. PMID: 27624167, PMCID: PMC5350067, DOI: 10.1111/jgh.13593.Peer-Reviewed Original ResearchConceptsEarly transjugular intrahepatic portosystemic shuntTransjugular intrahepatic portosystemic shuntAcute esophageal variceal bleedingEsophageal variceal bleedingIntrahepatic portosystemic shuntVariceal bleedingUS patientsPortosystemic shuntNationwide Inpatient Sample databaseHospital mortality rateUS clinical practiceDays of hospitalizationFurther bleedingHospital deathRecurrent bleedingEndoscopic therapyInpatient mortalityPreventive therapySecondary outcomesHepatic encephalopathyPrimary outcomeHigh riskHospital reductionMortality ratePatients
2016
Optimal timing for hepatitis C therapy in US patients eligible for liver transplantation: a cost‐effectiveness analysis
Njei B, McCarty TR, Fortune BE, Lim JK. Optimal timing for hepatitis C therapy in US patients eligible for liver transplantation: a cost‐effectiveness analysis. Alimentary Pharmacology & Therapeutics 2016, 44: 1090-1101. PMID: 27640785, DOI: 10.1111/apt.13798.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsBenzimidazolesCarcinoma, HepatocellularCost-Benefit AnalysisDisease ProgressionDrug Therapy, CombinationFluorenesGenotypeHepacivirusHepatitis CHumansLiver CirrhosisLiver NeoplasmsLiver TransplantationNeoplasm Recurrence, LocalQuality-Adjusted Life YearsRibavirinSofosbuvirUnited StatesConceptsHepatitis C virusLiver transplantationTime of transplantHCV recurrencePost-LTCost-effective strategyTreatment of HCVEnd-stage liver disease (MELD) scoreOptimal timingDonor LT recipientsLiver Disease scoreHCV genotype 1Hepatitis C therapyMarkov state transition modelHepatocellular carcinoma casesBase-case analysisSeparate treatment strategiesCost-effectiveness analysisAllograft failureDecompensated diseaseOngoing viraemiaPre-LTHCV treatmentLT recipientsMELD scorePrevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999‐2012
Njei B, Do A, Lim JK. Prevalence of hepatitis delta infection in the United States: National Health and Nutrition Examination Survey, 1999‐2012. Hepatology 2016, 64: 681-682. PMID: 26453027, PMCID: PMC4826621, DOI: 10.1002/hep.28279.Peer-Reviewed Original ResearchTrends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis
Njei B, McCarty TR, Birk JW. Trends in esophageal cancer survival in United States adults from 1973 to 2009: A SEER database analysis. Journal Of Gastroenterology And Hepatology 2016, 31: 1141-1146. PMID: 26749521, PMCID: PMC4885788, DOI: 10.1111/jgh.13289.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAge FactorsAgedCarcinoma, Squamous CellEarly Detection of CancerEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaEsophagectomyFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoplasm StagingPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk FactorsSEER ProgramSurvival RateTime FactorsTreatment OutcomeUnited StatesConceptsSquamous cell carcinomaEsophageal cancerEsophageal adenocarcinomaMedian survivalBetter long-term survival outcomesLong-term survival outcomesOverall median survivalEnd Results (SEER) databaseProportion of patientsSEER database analysisSignificant survival improvementProportional hazards regressionEsophageal cancer survivalLong-term survivalIndependent mortality factorsLocalized diseaseCurative stageSurgical treatmentSurvival improvementHazards regressionResults databaseSurvival outcomesCell carcinomaTreatment modalitiesCancer survival
2015
Emerging trends in hepatocellular carcinoma incidence and mortality
Njei B, Rotman Y, Ditah I, Lim JK. Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology 2015, 61: 191-199. PMID: 25142309, PMCID: PMC4823645, DOI: 10.1002/hep.27388.Peer-Reviewed Original ResearchConceptsIB mortalityHCC incidenceHepatocellular carcinomaIncidence of HCCMultivariable Cox regression analysisOverall median survivalCox regression analysisEnd Results (SEER) dataSignificant survival improvementAge-adjusted incidenceU.S. populationHepatocellular carcinoma incidenceJoinpoint Regression ProgramIncidence-based mortalityRegression analysisSignificant increaseCurative modalityLiver transplantCurative stageMedian survivalSurvival improvementCarcinoma incidenceTumor sizeVascular invasionPrimary tumor
2014
Risk of comorbidities and outcomes in patients with lower gastrointestinal bleeding-a nationwide study
Venkatesh PG, Njei B, Sanaka MR, Navaneethan U. Risk of comorbidities and outcomes in patients with lower gastrointestinal bleeding-a nationwide study. International Journal Of Colorectal Disease 2014, 29: 953-960. PMID: 24913253, PMCID: PMC4823646, DOI: 10.1007/s00384-014-1915-x.Peer-Reviewed Original ResearchConceptsLower gastrointestinal bleedingOutcomes of patientsYears of ageMortality rateGastrointestinal bleedingPrevalence of comorbiditiesRisk of comorbiditiesNumber of comorbiditiesPrimary discharge diagnosisCongestive heart failureImpact of comorbiditiesClinical Modification codesHealth care utilizationIdentification of comorbiditiesRisk of mortalityRisk-adjustment toolLogistic regression modelsHospital mortalityMore comorbiditiesComorbid illnessesElixhauser indexHospital stayRenal failureHeart failureOverall mortality