2019
Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF. Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. Gut 2019, 68: 1676. PMID: 31315892, PMCID: PMC7087395, DOI: 10.1136/gutjnl-2018-317811.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCalcium SignalingCarcinogenesisCarcinoma, HepatocellularCell ProliferationCells, CulturedDNA MethylationFemaleGene Expression Regulation, NeoplasticHepatocytesHumansInositol 1,4,5-Trisphosphate ReceptorsLiverLiver NeoplasmsLiver RegenerationMaleMice, KnockoutMiddle AgedSurvival AnalysisConceptsChronic liver diseaseITPR3 expressionLiver cancer cellsLiver diseaseMouse modelFinal common eventCancer cellsSpecimens of patientsIndependent patient cohortsControl liver specimensHuman HCC cellsType 3 InsP3 receptorHuman liver samplesIncreased expression levelCancer deathPatient cohortCommon molecular eventPoor survivalHepatocellular carcinomaLiver specimensNormal liverHCC cellsAbstractTextHCCType 3 isoform
2015
Comparative efficacy of antiviral therapy in preventing vertical transmission of hepatitis B: a network meta‐analysis
Njei B, Gupta N, Ewelukwa O, Ditah I, Foma M, Lim JK. Comparative efficacy of antiviral therapy in preventing vertical transmission of hepatitis B: a network meta‐analysis. Liver International 2015, 36: 634-641. PMID: 26352650, PMCID: PMC4824664, DOI: 10.1111/liv.12959.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsFemaleHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHepatitis B, ChronicHumansInfant, NewbornInfectious Disease Transmission, VerticalNetwork Meta-AnalysisPregnancyPregnancy Complications, InfectiousRandomized Controlled Trials as TopicTelbivudineThymidineViral LoadConceptsHepatitis B virusClinical trialsVertical transmissionSeropositive mothersB virusAntiviral drugsComparative efficacyHepatitis B e antigenEfficacy of tenofovirHepatitis B immunizationIndirect treatment comparisonHigh viral loadHBV infectionIntrauterine transmissionHepatitis BAntiviral therapyB immunizationE antigenThird trimesterViral loadChinese patientsGravid motherAbstractTextComprehensive searchTreatment comparisons