2016
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model
Kaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biological Psychiatry 2016, 81: 503-513. PMID: 27450031, PMCID: PMC5130616, DOI: 10.1016/j.biopsych.2016.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBiomarkersBrainDecision MakingDiffusion Tensor ImagingDisease Models, AnimalFemaleMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMethylazoxymethanol AcetateMultimodal ImagingPrefrontal CortexRatsRats, Sprague-DawleyReversal LearningRewardSchizophreniaSchizophrenic PsychologyConceptsMAM ratsEarly schizophreniaReversal-learning taskEarly behavioral markersResting-state functional magnetic resonanceFunctional magnetic resonanceMethylazoxymethanol acetate (MAM) rat modelFunctional brain biomarkersPerceptual problemsBehavioral markersOrbitofrontal cortexLate adolescenceFunctional connectivityRat modelEarly diagnosisThree-choiceBehavioral studiesBehavioral symptomsPosterior corpus callosumSubstance abuseProdromal patientsSubthreshold symptomsVisual cortexBrain biomarkersSaline-treated controls
2015
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure
Coman D, Sanganahalli BG, Jiang L, Hyder F, Behar KL. Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure. NMR In Biomedicine 2015, 28: 1257-1266. PMID: 26286889, PMCID: PMC4573923, DOI: 10.1002/nbm.3375.Peer-Reviewed Original ResearchConceptsNeurovascular couplingBlood flowNeuronal activityNeural activityWhole-body hyperthermiaAbused psychostimulantMethylenedioxymethamphetamine (MDMA) exposureNeurovascular responseCortex temperatureMDMA effectsRat cortexRat brainBrain temperatureSubcortical regionsBrain regionsCortexSubcortexMDMA actionSkeletal muscleMonoaminergic stimulationBrainMDMACBFBody temperatureThermogenesis
2013
Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging
Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging. Magnetic Resonance Imaging 2013, 32: 305-313. PMID: 24581725, PMCID: PMC3965601, DOI: 10.1016/j.mri.2013.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBrainFluorodeoxyglucose F18Glucose-6-PhosphateMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMetabolic Clearance RateMolecular ImagingPhosphorylationPhosphotransferasesRadionuclide ImagingRadiopharmaceuticalsRatsRats, Inbred LewReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsRat brainChemical shift imagingHalothane-anesthetized ratsMagnetic resonance spectroscopy studyTotal glucose metabolismMinimal side effectsMagnetic resonance imaging (MRI) measurementsFunctional magnetic resonance imaging (fMRI) measurementsFDG phosphorylationFMRI BOLD responsesCerebral physiologyForepaw stimulationShift imagingGlucose metabolismSide effectsBrain tissueFDGExtracted tissuesTumor pathophysiologyBrainMRS measurementsTissue componentsVivo detectionVivoD-glucoseLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain