2020
APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease
Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiology Of Disease 2020, 139: 104834. PMID: 32173556, PMCID: PMC7486698, DOI: 10.1016/j.nbd.2020.104834.Peer-Reviewed Original ResearchConceptsCerebral blood flowAsymptomatic APOE4 carriersE4FAD miceAPOE4 carriersAlzheimer's diseaseCerebrovascular reactivityNeurotransmitter levelsE3FAD micePharmacogenetic responsePharmacogenetic differencesSomatosensory responsesBlood-brain barrier functionBrain functionStrongest genetic risk factorBrain metabolic changesFree fatty acid levelsAmyloid-beta plaquesHuman APOE4 geneDifferent APOE allelesAPOE ε3 alleleFuture clinical testingGenetic risk factorsFatty acid levelsWhite matter integrityAβ transport
2013
Functional MRI and neural responses in a rat model of Alzheimer's disease
Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-411. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional magnetic resonance imagingCerebral cortexAD brainSomatosensory cortexRat modelCortical functionNeural responsesAge-matched healthy controlsAD rat modelContralateral somatosensory cortexSensory-evoked responsesHigh-field functional magnetic resonance imagingBrain functional responsesMagnetic resonance imagingAD ratsControl ratsHealthy controlsThalamic responsesNormal ratsCortical responsesAD modelSubcortical functionBrain plaquesElectrical stimulation