2020
Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence
Parent M, Chitturi J, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence. Journal Of Neurotrauma 2020, 37: 966-974. PMID: 31830867, PMCID: PMC7175625, DOI: 10.1089/neu.2019.6486.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsBrainBrain Injuries, TraumaticKaempferolsMagnetic Resonance ImagingMaleNerve NetParenchymal TissueRatsRats, Sprague-DawleyTreatment OutcomeConceptsTraumatic brain injuryKaempferol treatmentDiffusion tensor imagingFractional anisotropyBrain injuryParenchymal microstructureCallosal fractional anisotropyInterhemispheric structural connectivityH post-TBINeural connectivitySelect brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingTBI prognosisCerebrovascular reactivityFunctional outcomeImaging outcomesNeurovascular couplingPost-TBITBI outcomesTBI pathophysiologyMetabolic benefitsResting-state functional connectivity networksRsFC changesWhole brain
2018
Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development
Parent M, Li Y, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development. Journal Of Neurotrauma 2018, 36: 601-608. PMID: 29855211, PMCID: PMC6354598, DOI: 10.1089/neu.2018.5741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain Injuries, TraumaticCerebrovascular CirculationMagnetic Resonance ImagingMaleNeural PathwaysRatsRats, Sprague-DawleyConceptsTraumatic brain injuryDevelopmental traumatic brain injuryResting-state functional connectivityDiffusion tensor imagingCerebrovascular resistanceIpsilateral hippocampusBrain injuryLateral fluid percussion traumatic brain injuryFluid percussion traumatic brain injuryNeuronal connectivityFunctional MRIModerate traumatic brain injuryParenchymal microstructureInterhemispheric structural connectivityFluid percussion injuryCortical blood flowNeural connectivityMicrostructural integrityInterhemispheric asymmetryIpsilateral thalamusNeurovascular functionCerebrovascular reactivityMotor cortexRSFC strengthSubcortical alterations