2023
A consensus protocol for functional connectivity analysis in the rat brain
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière D, Blockx I, Bortel A, Broadwater M, Cardoso B, Célestine M, Chavez-Negrete J, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes F, Fowler C, Fuentes-Ibañez A, Garin C, Gelderman E, Golden C, Guo C, Henckens M, Hennessy L, Herman P, Hofwijks N, Horien C, Ionescu T, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee S, Lillywhite A, Liu Y, Liu Y, López -Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan M, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens D, Nava-Gomez L, Nonaka H, Ortiz J, Paasonen J, Peeters L, Pereira M, Perez P, Pompilus M, Prior M, Rakhmatullin R, Reimann H, Reinwald J, Del Rio R, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten T, Ryoke R, Sack M, Salvan P, Sanganahalli B, Schroeter A, Seewoo B, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith J, Smith C, Sobczak F, Stenroos P, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García M, Tudela R, van den Berg M, van der Marel K, van Hout A, Vertullo R, Vidal B, Vrooman R, Wang V, Wank I, Watson D, Yin T, Zhang Y, Zurbruegg S, Achard S, Alcauter S, Auer D, Barbier E, Baudewig J, Beckmann C, Beckmann N, Becq G, Blezer E, Bolbos R, Boretius S, Bouvard S, Budinger E, Buxbaum J, Cash D, Chapman V, Chuang K, Ciobanu L, Coolen B, Dalley J, Dhenain M, Dijkhuizen R, Esteban O, Faber C, Febo M, Feindel K, Forloni G, Fouquet J, Garza-Villarreal E, Gass N, Glennon J, Gozzi A, Gröhn O, Harkin A, Heerschap A, Helluy X, Herfert K, Heuser A, Homberg J, Houwing D, Hyder F, Ielacqua G, Jelescu I, Johansen-Berg H, Kaneko G, Kawashima R, Keilholz S, Keliris G, Kelly C, Kerskens C, Khokhar J, Kind P, Langlois J, Lerch J, López-Hidalgo M, Manahan-Vaughan D, Marchand F, Mars R, Marsella G, Micotti E, Muñoz-Moreno E, Near J, Niendorf T, Otte W, Pais-Roldán P, Pan W, Prado-Alcalá R, Quirarte G, Rodger J, Rosenow T, Sampaio-Baptista C, Sartorius A, Sawiak S, Scheenen T, Shemesh N, Shih Y, Shmuel A, Soria G, Stoop R, Thompson G, Till S, Todd N, Van Der Linden A, van der Toorn A, van Tilborg G, Vanhove C, Veltien A, Verhoye M, Wachsmuth L, Weber-Fahr W, Wenk P, Yu X, Zerbi V, Zhang N, Zhang B, Zimmer L, Devenyi G, Chakravarty M, Hess A. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience 2023, 26: 673-681. PMID: 36973511, PMCID: PMC10493189, DOI: 10.1038/s41593-023-01286-8.Peer-Reviewed Original Research
2018
Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb
Thompson GJ, Sanganahalli BG, Baker KL, Herman P, Shepherd GM, Verhagen JV, Hyder F. Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. NeuroImage 2018, 172: 586-596. PMID: 29374582, PMCID: PMC5910178, DOI: 10.1016/j.neuroimage.2018.01.051.Peer-Reviewed Original Research
2016
Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. Progress In Brain Research 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.Peer-Reviewed Original ResearchConceptsNeurovascular couplingFunctional MRINeuronal activityBlood oxygenation level-dependent (BOLD) signalFunctional brain activationLevel-dependent signalNeurometabolic couplingEffective therapyBlood flowNeuroimaging toolsHealth conditionsPowerful neuroimaging toolBrain activationBOLD signalNeural activityBOLD contrastMetabolic demandsOxygen consumptionDependent signalsTherapyMicrovesselsMRIActivityBiomarkers
2015
Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping
Sanganahalli BG, Rebello MR, Herman P, Papademetris X, Shepherd GM, Verhagen JV, Hyder F. Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. NeuroImage 2015, 126: 208-218. PMID: 26631819, PMCID: PMC4733588, DOI: 10.1016/j.neuroimage.2015.11.048.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHigh-resolution functional magnetic resonance imagingPost-synaptic activityPre-synaptic inputOlfactory bulb glomeruliFunctional imaging signalsWide-field calcium imagingMagnetic resonance imagingHemodynamic eventsAnesthetized ratsGlomerular layerNeuronal circuitryGlomerular clustersGlomerular patternNeuropil regionsCalcium imagingDye imagingResonance imagingActivity patternsDeoxyhemoglobin contrastGlomerular activity patternsGlomerular sheetGlomerular networkGlomeruliBrain region and activity-dependent properties of M for calibrated fMRI
Shu CY, Herman P, Coman D, Sanganahalli BG, Wang H, Juchem C, Rothman DL, de Graaf RA, Hyder F. Brain region and activity-dependent properties of M for calibrated fMRI. NeuroImage 2015, 125: 848-856. PMID: 26529646, PMCID: PMC4691415, DOI: 10.1016/j.neuroimage.2015.10.083.Peer-Reviewed Original ResearchRole of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks
Kannurpatti SS, Sanganahalli BG, Herman P, Hyder F. Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR In Biomedicine 2015, 28: 1579-1588. PMID: 26439799, PMCID: PMC4621005, DOI: 10.1002/nbm.3421.Peer-Reviewed Original ResearchConceptsSimilar dose-dependent decreaseDose-dependent decreaseCaudate putamenBrain regionsBlood oxygen level-dependent fluctuationsBrain energy metabolismLevel-dependent fluctuationsBrain functional organizationSomatosensory cortexAnesthetized ratsDifferent functional networksFunctional organizationDrug treatmentVascular densityHippocampal regionThalamic regionsDifferent physiological impactsBOLD fluctuationsRSFC networksIntrinsic activityState fMRINeural signalingBrain networksPutamenFMRI brain networksRhythmic 3–4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures
Youngblood MW, Chen WC, Mishra AM, Enamandram S, Sanganahalli BG, Motelow JE, Bai HX, Frohlich F, Gribizis A, Lighten A, Hyder F, Blumenfeld H. Rhythmic 3–4Hz discharge is insufficient to produce cortical BOLD fMRI decreases in generalized seizures. NeuroImage 2015, 109: 368-377. PMID: 25562830, PMCID: PMC4340775, DOI: 10.1016/j.neuroimage.2014.12.066.Peer-Reviewed Original ResearchConceptsHz spike-wave dischargesSpike-wave dischargesFMRI decreasesSpike-wave seizuresAnimal modelsHuman patientsMagnetic resonance imaging studyTonic-clonic seizuresBlood oxygen level-dependent (BOLD) signalResonance imaging studyFunctional magnetic resonance imaging studyHuman functional magnetic resonance imaging (fMRI) studiesGeneralized seizuresFerret modelCortical decreasesAbsence seizuresCortical developmentAnesthetic regimeSeizuresTransient episodesHuman seizuresImaging studiesPatientsBOLD fMRISimultaneous electroencephalography
2013
Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats
Mishra AM, Bai X, Motelow JE, DeSalvo MN, Danielson N, Sanganahalli BG, Hyder F, Blumenfeld H. Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats. Epilepsia 2013, 54: 1214-1222. PMID: 23815571, PMCID: PMC3703864, DOI: 10.1111/epi.12227.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesWAG/RijFunctional connectivityNonepileptic controlsAbsence epilepsyEpileptic WAG/RijBrain networksWAG/Rij ratsChronic seizure activitySpike-wave epilepsyHuman absence seizuresChildhood absence epilepsyWistar Albino GlaxoActivity-dependent plasticityCortical-cortical connectivityFunctional magnetic resonance imagingMagnetic resonance imagingNonepileptic animalsSeizure activitySpontaneous episodesWistar controlsAbsence seizuresAdjacent cortexChronic changesAnimal modelsFunctional MRI and neural responses in a rat model of Alzheimer's disease
Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-411. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional magnetic resonance imagingCerebral cortexAD brainSomatosensory cortexRat modelCortical functionNeural responsesAge-matched healthy controlsAD rat modelContralateral somatosensory cortexSensory-evoked responsesHigh-field functional magnetic resonance imagingBrain functional responsesMagnetic resonance imagingAD ratsControl ratsHealthy controlsThalamic responsesNormal ratsCortical responsesAD modelSubcortical functionBrain plaquesElectrical stimulation
2012
Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System
Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F. Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System. Cerebral Cortex 2012, 23: 210-222. PMID: 22298731, PMCID: PMC3513959, DOI: 10.1093/cercor/bhs008.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGeneral linear modelingSuperior colliculusBOLD responseBasal blood flowNeural activityRat visual systemBlood oxygenation level-dependent (BOLD) responsePrimary visual cortexMagnetic resonance imagingLevel-dependent responsesNeurovascular couplingRat brainBlood flowVisual cortexResonance imagingStimulation paradigmV1 signalsLight flashesOnset/Neural signalsResponseV1Visual systemColliculus
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal modelsRole of Ongoing, Intrinsic Activity of Neuronal Populations for Quantitative Neuroimaging of Functional Magnetic Resonance Imaging–Based Networks
Hyder F, Herman P, Sanganahalli BG, Coman D, Blumenfeld H, Rothman DL. Role of Ongoing, Intrinsic Activity of Neuronal Populations for Quantitative Neuroimaging of Functional Magnetic Resonance Imaging–Based Networks. Brain Connectivity 2011, 1: 185-193. PMID: 22433047, PMCID: PMC3621320, DOI: 10.1089/brain.2011.0032.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEnergy/activityMagnetic resonance imagingBOLD signalNeuronal activityQuantitative neuroimagingNeuronal populationsResonance imagingBaseline BOLD signalsTotal neuronal activityBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalResting-state fMRI experimentsAnimal modelsFMRI experimentMagnetic resonance spectroscopy measurementsBrain networksBaselineNeuroimagingPrimary objectiveImagingIntrinsic activityActivityPopulation