2015
Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks
Kannurpatti SS, Sanganahalli BG, Herman P, Hyder F. Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR In Biomedicine 2015, 28: 1579-1588. PMID: 26439799, PMCID: PMC4621005, DOI: 10.1002/nbm.3421.Peer-Reviewed Original ResearchConceptsSimilar dose-dependent decreaseDose-dependent decreaseCaudate putamenBrain regionsBlood oxygen level-dependent fluctuationsBrain energy metabolismLevel-dependent fluctuationsBrain functional organizationSomatosensory cortexAnesthetized ratsDifferent functional networksFunctional organizationDrug treatmentVascular densityHippocampal regionThalamic regionsDifferent physiological impactsBOLD fluctuationsRSFC networksIntrinsic activityState fMRINeural signalingBrain networksPutamenFMRI brain networks
2013
Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats
Mishra AM, Bai X, Motelow JE, DeSalvo MN, Danielson N, Sanganahalli BG, Hyder F, Blumenfeld H. Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats. Epilepsia 2013, 54: 1214-1222. PMID: 23815571, PMCID: PMC3703864, DOI: 10.1111/epi.12227.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesWAG/RijFunctional connectivityNonepileptic controlsAbsence epilepsyEpileptic WAG/RijBrain networksWAG/Rij ratsChronic seizure activitySpike-wave epilepsyHuman absence seizuresChildhood absence epilepsyWistar Albino GlaxoActivity-dependent plasticityCortical-cortical connectivityFunctional magnetic resonance imagingMagnetic resonance imagingNonepileptic animalsSeizure activitySpontaneous episodesWistar controlsAbsence seizuresAdjacent cortexChronic changesAnimal modelsMitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI. PLOS ONE 2013, 8: e63317. PMID: 23650561, PMCID: PMC3641133, DOI: 10.1371/journal.pone.0063317.Peer-Reviewed Original ResearchConceptsSpontaneous neuronal activityNeuronal activityCerebral blood flow fluctuationsFunctional connectivityRelevant translational modelState functional connectivityTraumatic brain injuryBlood flow fluctuationsIntrinsic brain activityBrain functional connectivityResting-state fMRIMitochondrial functional stateNeuronal electrical activityFunctional stateReduced RSFCNeural metabolismBrain injuryHemodynamic fluctuationsHemodynamic responseMCU inhibitionNeocortical activityBOLD fluctuationsTranslational modelState fMRIBOLD response