2023
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, Kim S, Cabeen R, Koenig J, Akhter K, Arbab A, Avery B, Beatty H, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman A, Hyder F, Imai T, Johnson C, Khan M, Kamat P, Karuppagounder S, Kumskova M, Mihailovic J, Mandeville J, Morais A, Patel R, Sanganahalli B, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez S, Aronowski J, Ayata C, Chauhan A, Leira E, Hess D, Koehler R, McCullough L, Sansing L. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science Translational Medicine 2023, 15: eadg8656. PMID: 37729432, DOI: 10.1126/scitranslmed.adg8656.Peer-Reviewed Original ResearchConceptsPreclinical assessmentFocal cerebral ischemic insultAcute ischemic strokeCerebral ischemic insultLarge clinical trialsDiet-induced obesityNew clinical interventionsIntravascular thrombectomyIschemic strokeStroke treatmentHypertensive ratsIschemic insultBlinded assessmentClinical trialsYoung miceTreatment candidatesExclusion criteriaAnimal modelsYoung ratsFutile interventionsPreclinical trialsClinical interventionsFutility boundariesMiceDisease areas
2004
Glutamate-induced differential mitochondrial response in young and adult rats
Kannurpatti S, Sanganahalli B, Mishra S, Joshi P, Joshi N. Glutamate-induced differential mitochondrial response in young and adult rats. Neurochemistry International 2004, 44: 361-369. PMID: 14643754, DOI: 10.1016/s0197-0186(03)00164-5.Peer-Reviewed Original ResearchConceptsAdult ratsLDH releaseYoung ratsIntracellular calciumLactate dehydrogenaseReactive oxygen speciesExcitatory amino acid glutamateIntracellular calcium changesGlutamate-induced increaseTreatment of slicesGlutamate-induced decreaseAge groupsInfluence of glutamateMitochondrial depolarizationAmino acid glutamateMitochondrial inhibitor rotenoneCortical slicesCalcium changesReactive oxygen species formationNeuronal cell deathGlutamate stimulationGlutamate treatmentMitochondrial functionAcid glutamateCa(2+