2016
Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model
Kaneko G, Sanganahalli BG, Groman SM, Wang H, Coman D, Rao J, Herman P, Jiang L, Rich K, de Graaf RA, Taylor JR, Hyder F. Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biological Psychiatry 2016, 81: 503-513. PMID: 27450031, PMCID: PMC5130616, DOI: 10.1016/j.biopsych.2016.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBiomarkersBrainDecision MakingDiffusion Tensor ImagingDisease Models, AnimalFemaleMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMethylazoxymethanol AcetateMultimodal ImagingPrefrontal CortexRatsRats, Sprague-DawleyReversal LearningRewardSchizophreniaSchizophrenic PsychologyConceptsMAM ratsEarly schizophreniaReversal-learning taskEarly behavioral markersResting-state functional magnetic resonanceFunctional magnetic resonanceMethylazoxymethanol acetate (MAM) rat modelFunctional brain biomarkersPerceptual problemsBehavioral markersOrbitofrontal cortexLate adolescenceFunctional connectivityRat modelEarly diagnosisThree-choiceBehavioral studiesBehavioral symptomsPosterior corpus callosumSubstance abuseProdromal patientsSubthreshold symptomsVisual cortexBrain biomarkersSaline-treated controls
2012
Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System
Bailey CJ, Sanganahalli BG, Herman P, Blumenfeld H, Gjedde A, Hyder F. Analysis of Time and Space Invariance of BOLD Responses in the Rat Visual System. Cerebral Cortex 2012, 23: 210-222. PMID: 22298731, PMCID: PMC3513959, DOI: 10.1093/cercor/bhs008.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGeneral linear modelingSuperior colliculusBOLD responseBasal blood flowNeural activityRat visual systemBlood oxygenation level-dependent (BOLD) responsePrimary visual cortexMagnetic resonance imagingLevel-dependent responsesNeurovascular couplingRat brainBlood flowVisual cortexResonance imagingStimulation paradigmV1 signalsLight flashesOnset/Neural signalsResponseV1Visual systemColliculus