2020
Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence
Parent M, Chitturi J, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence. Journal Of Neurotrauma 2020, 37: 966-974. PMID: 31830867, PMCID: PMC7175625, DOI: 10.1089/neu.2019.6486.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryKaempferol treatmentDiffusion tensor imagingFractional anisotropyBrain injuryParenchymal microstructureCallosal fractional anisotropyInterhemispheric structural connectivityH post-TBINeural connectivitySelect brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingTBI prognosisCerebrovascular reactivityFunctional outcomeImaging outcomesNeurovascular couplingPost-TBITBI outcomesTBI pathophysiologyMetabolic benefitsResting-state functional connectivity networksRsFC changesWhole brain
2018
Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development
Parent M, Li Y, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development. Journal Of Neurotrauma 2018, 36: 601-608. PMID: 29855211, PMCID: PMC6354598, DOI: 10.1089/neu.2018.5741.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDevelopmental traumatic brain injuryResting-state functional connectivityDiffusion tensor imagingCerebrovascular resistanceIpsilateral hippocampusBrain injuryLateral fluid percussion traumatic brain injuryFluid percussion traumatic brain injuryNeuronal connectivityFunctional MRIModerate traumatic brain injuryParenchymal microstructureInterhemispheric structural connectivityFluid percussion injuryCortical blood flowNeural connectivityMicrostructural integrityInterhemispheric asymmetryIpsilateral thalamusNeurovascular functionCerebrovascular reactivityMotor cortexRSFC strengthSubcortical alterations
2014
Decreased Resting Functional Connectivity after Traumatic Brain Injury in the Rat
Mishra AM, Bai X, Sanganahalli BG, Waxman SG, Shatillo O, Grohn O, Hyder F, Pitkänen A, Blumenfeld H. Decreased Resting Functional Connectivity after Traumatic Brain Injury in the Rat. PLOS ONE 2014, 9: e95280. PMID: 24748279, PMCID: PMC3991600, DOI: 10.1371/journal.pone.0095280.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryContralateral parietal cortexSham-operated animalsFunctional magnetic resonance imagingParietal cortexFunctional connectivityFunctional imagingBrain injuryAdult male Sprague-Dawley ratsLateral fluid percussion injuryExperimental traumatic brain injuryMale Sprague-Dawley ratsFluid percussion injuryPost-traumatic epileptogenesisSeizure-susceptibility testState BOLD-fMRISide of injuryAbnormal functional connectivitySham-operated ratsSprague-Dawley ratsMagnetic resonance imagingSeizure susceptibilitySkull electrodesEpileptiform dischargesFunctional imaging data
2013
Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI. PLOS ONE 2013, 8: e63317. PMID: 23650561, PMCID: PMC3641133, DOI: 10.1371/journal.pone.0063317.Peer-Reviewed Original ResearchConceptsSpontaneous neuronal activityNeuronal activityCerebral blood flow fluctuationsFunctional connectivityRelevant translational modelState functional connectivityTraumatic brain injuryBlood flow fluctuationsIntrinsic brain activityBrain functional connectivityResting-state fMRIMitochondrial functional stateNeuronal electrical activityFunctional stateReduced RSFCNeural metabolismBrain injuryHemodynamic fluctuationsHemodynamic responseMCU inhibitionNeocortical activityBOLD fluctuationsTranslational modelState fMRIBOLD response