2022
Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury
Sanganahalli B, Pavuluri S, Chitturi J, Herman P, Elkabes S, Heary R, Hyder F, Kannurpatti S. Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury. Neurotrauma Reports 2022, 3: 421-432. PMID: 36337081, PMCID: PMC9622206, DOI: 10.1089/neur.2022.0040.Peer-Reviewed Original ResearchMotor dysfunctionMotor networkCervical spinal cord injuryMotor functional recoverySpinal cord injuryFunctional connectivity correlatesSensory-motor integrationSupraspinal changesCervical SCIDeafferented sideSCI patientsUnaffected hemisphereFunctional recoverySupraspinal regionsClinical evidenceNociceptive activityCord injurySpinal cordLeft predominanceMaladaptive reorganizationRat modelPainConnectivity correlatesLarger painState fMRI
2021
Supraspinal Sensorimotor and Pain-Related Reorganization after a Hemicontusion Rat Cervical Spinal Cord Injury
Sanganahalli BG, Chitturi J, Herman P, Elkabes S, Heary R, Hyder F, Kannurpatti SS. Supraspinal Sensorimotor and Pain-Related Reorganization after a Hemicontusion Rat Cervical Spinal Cord Injury. Journal Of Neurotrauma 2021, 38: 3393-3405. PMID: 34714150, PMCID: PMC8713267, DOI: 10.1089/neu.2021.0190.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryAnterior cingulate cortexFunctional magnetic resonance imagingPre-frontal cortexNociceptive regionsCord injuryPresence of painSecondary somatosensory cortexFunctional connectivity densityElectrical forepaw stimulationFemale adult ratsTranslational animal modelsMost cortical regionsMagnetic resonance imagingDiscernable lesionsIpsilesional forelimbKdyn forceRSFC decreasesRsFC increasesSupraspinal changesMotor recoveryThermal hyperalgesiaT2 lesionsPain behavior