2022
Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury
Sanganahalli B, Pavuluri S, Chitturi J, Herman P, Elkabes S, Heary R, Hyder F, Kannurpatti S. Lateralized Supraspinal Functional Connectivity Correlate with Pain and Motor Dysfunction in Rat Hemicontusion Cervical Spinal Cord Injury. Neurotrauma Reports 2022, 3: 421-432. PMID: 36337081, PMCID: PMC9622206, DOI: 10.1089/neur.2022.0040.Peer-Reviewed Original ResearchMotor dysfunctionMotor networkCervical spinal cord injuryMotor functional recoverySpinal cord injuryFunctional connectivity correlatesSensory-motor integrationSupraspinal changesCervical SCIDeafferented sideSCI patientsUnaffected hemisphereFunctional recoverySupraspinal regionsClinical evidenceNociceptive activityCord injurySpinal cordLeft predominanceMaladaptive reorganizationRat modelPainConnectivity correlatesLarger painState fMRI
2015
Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks
Kannurpatti SS, Sanganahalli BG, Herman P, Hyder F. Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR In Biomedicine 2015, 28: 1579-1588. PMID: 26439799, PMCID: PMC4621005, DOI: 10.1002/nbm.3421.Peer-Reviewed Original ResearchConceptsSimilar dose-dependent decreaseDose-dependent decreaseCaudate putamenBrain regionsBlood oxygen level-dependent fluctuationsBrain energy metabolismLevel-dependent fluctuationsBrain functional organizationSomatosensory cortexAnesthetized ratsDifferent functional networksFunctional organizationDrug treatmentVascular densityHippocampal regionThalamic regionsDifferent physiological impactsBOLD fluctuationsRSFC networksIntrinsic activityState fMRINeural signalingBrain networksPutamenFMRI brain networks
2013
Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Functional State Impacts Spontaneous Neocortical Activity and Resting State fMRI. PLOS ONE 2013, 8: e63317. PMID: 23650561, PMCID: PMC3641133, DOI: 10.1371/journal.pone.0063317.Peer-Reviewed Original ResearchConceptsSpontaneous neuronal activityNeuronal activityCerebral blood flow fluctuationsFunctional connectivityRelevant translational modelState functional connectivityTraumatic brain injuryBlood flow fluctuationsIntrinsic brain activityBrain functional connectivityResting-state fMRIMitochondrial functional stateNeuronal electrical activityFunctional stateReduced RSFCNeural metabolismBrain injuryHemodynamic fluctuationsHemodynamic responseMCU inhibitionNeocortical activityBOLD fluctuationsTranslational modelState fMRIBOLD response