2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic waste
2020
Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI
Sanganahalli BG, Baker KL, Thompson GJ, Herman P, Shepherd GM, Verhagen JV, Hyder F. Orthonasal versus retronasal glomerular activity in rat olfactory bulb by fMRI. NeuroImage 2020, 212: 116664. PMID: 32087375, PMCID: PMC9362851, DOI: 10.1016/j.neuroimage.2020.116664.Peer-Reviewed Original ResearchConceptsRat olfactory bulbOlfactory bulbWhole olfactory bulbOlfactory receptor neuronsFunctional MRINasal cavityRetronasal stimuliGlomerular sheetDorsal-medial regionsDelivery routeRetronasal stimulationSimilar response amplitudesGlomerular activityFMRI activation mapsSame odorReceptor neuronsDorsal regionNeural responsesOdor representationsLateral regionsSame odorantOrthonasalUnderlie differencesResponse amplitudeResponse patterns