Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging
Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging. Magnetic Resonance Imaging 2013, 32: 305-313. PMID: 24581725, PMCID: PMC3965601, DOI: 10.1016/j.mri.2013.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBrainFluorodeoxyglucose F18Glucose-6-PhosphateMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMetabolic Clearance RateMolecular ImagingPhosphorylationPhosphotransferasesRadionuclide ImagingRadiopharmaceuticalsRatsRats, Inbred LewReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsRat brainChemical shift imagingHalothane-anesthetized ratsMagnetic resonance spectroscopy studyTotal glucose metabolismMinimal side effectsMagnetic resonance imaging (MRI) measurementsFunctional magnetic resonance imaging (fMRI) measurementsFDG phosphorylationFMRI BOLD responsesCerebral physiologyForepaw stimulationShift imagingGlucose metabolismSide effectsBrain tissueFDGExtracted tissuesTumor pathophysiologyBrainMRS measurementsTissue componentsVivo detectionVivoD-glucoseLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain