2021
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrain
2015
Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy
Song Y, Sanganahalli BG, Hyder F, Lin WC, Riera JJ. Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy. PLOS ONE 2015, 10: e0134352. PMID: 26226628, PMCID: PMC4520590, DOI: 10.1371/journal.pone.0134352.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesResting-state networksFocal epilepsyIrritative zoneBOLD responseType of epilepsyConnected brain areasLevel-dependent responsesDefault mode networkFocal epileptogenesisChronic modelBOLD deactivationEpileptiform dischargesBrain areasAltered spatial patternSubcortical structuresEpilepsyMode networkEEG recordingsAlterationsDifferent brain modulesConnectivity patternsIndividual alterationsBrain modulesDifferent manifestations