2013
Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 1115-1126. PMID: 23591650, PMCID: PMC3705442, DOI: 10.1038/jcbfm.2013.61.Peer-Reviewed Original ResearchConceptsSensory-evoked cortical activityCentral nervous system metabolismCerebral blood flowCortical neuronal activityStimulus-evoked responsesCentral nervous systemBlood oxygen level dependenceNeocortical excitabilityBrain signalingHemodynamic responseBlood flowNeuronal activityNervous systemCortical activityNeocortical activityCalcium changesExtracellular electrophysiologyMCU activityMCU inhibitorVivo impactVivo mitochondriaDependent mannerMultiple subcellular compartmentsRole of mitochondriaUniporter activity
2004
Glutamate-induced differential mitochondrial response in young and adult rats
Kannurpatti S, Sanganahalli B, Mishra S, Joshi P, Joshi N. Glutamate-induced differential mitochondrial response in young and adult rats. Neurochemistry International 2004, 44: 361-369. PMID: 14643754, DOI: 10.1016/s0197-0186(03)00164-5.Peer-Reviewed Original ResearchConceptsAdult ratsLDH releaseYoung ratsIntracellular calciumLactate dehydrogenaseReactive oxygen speciesExcitatory amino acid glutamateIntracellular calcium changesGlutamate-induced increaseTreatment of slicesGlutamate-induced decreaseAge groupsInfluence of glutamateMitochondrial depolarizationAmino acid glutamateMitochondrial inhibitor rotenoneCortical slicesCalcium changesReactive oxygen species formationNeuronal cell deathGlutamate stimulationGlutamate treatmentMitochondrial functionAcid glutamateCa(2+