APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease
Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiology Of Disease 2020, 139: 104834. PMID: 32173556, PMCID: PMC7486698, DOI: 10.1016/j.nbd.2020.104834.Peer-Reviewed Original ResearchConceptsCerebral blood flowAsymptomatic APOE4 carriersE4FAD miceAPOE4 carriersAlzheimer's diseaseCerebrovascular reactivityNeurotransmitter levelsE3FAD micePharmacogenetic responsePharmacogenetic differencesSomatosensory responsesBlood-brain barrier functionBrain functionStrongest genetic risk factorBrain metabolic changesFree fatty acid levelsAmyloid-beta plaquesHuman APOE4 geneDifferent APOE allelesAPOE ε3 alleleFuture clinical testingGenetic risk factorsFatty acid levelsWhite matter integrityAβ transport