2024
Long-term follow up of E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group.
Burtness B, Flamand Y, Quon H, Weinstein G, Mehra R, Garcia J, Kim S, O'malley B, Ozer E, Koch W, Gross N, Bell R, Patel M, Lango M, Morris L, Smith R, Karakla D, Richmon J, Holsinger F, Ferris R. Long-term follow up of E3311, a phase II trial of transoral surgery (TOS) followed by pathology-based adjuvant treatment in HPV-associated (HPV+) oropharynx cancer (OPC): A trial of the ECOG-ACRIN Cancer Research Group. Journal Of Clinical Oncology 2024, 42: 6009-6009. DOI: 10.1200/jco.2024.42.16_suppl.6009.Peer-Reviewed Original ResearchProgression-free survivalIntermediate risk patientsExtranodal extensionOverall survivalPhase II trialRisk patientsSmoking historyPack-yearsPrimary siteLong-term follow-upFavorable pathologic characteristicsMature outcome dataPrescribed radiation doseECOG-ACRIN Cancer Research GroupPost-operative radiationIncreased recurrence riskKaplan-Meier methodLog-rank testPost-operative managementCancer Research GroupHPV+ OPCWeekly cisplatinMedian followN1 diseaseN1 patients
2023
Top advances of the year: Head and neck cancer
Verma A, Burtness B. Top advances of the year: Head and neck cancer. Cancer 2023, 129: 1308-1312. PMID: 36692372, DOI: 10.1002/cncr.34654.Peer-Reviewed Original ResearchConceptsProgression-free survivalFavorable-risk patientsRisk patientsNeck cancerHuman papillomavirus-associated oropharyngeal cancerGemcitabine/cisplatin chemotherapyImmature survival dataVirus-related cancersIntermediate-risk patientsFirst-line treatmentPhase 3 trialCooperative group trialsTreatment deintensificationMetastatic headOverall survivalPostoperative therapySmoking historyOropharyngeal cancerAntibody nivolumabCisplatin chemotherapyTransoral resectionTransoral surgeryNasopharyngeal cancerGroup trialsGy radiation
2012
Management of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Cancer
Mehra R, Ang KK, Burtness B. Management of Human Papillomavirus–Positive and Human Papillomavirus–Negative Head and Neck Cancer. Seminars In Radiation Oncology 2012, 22: 194-197. PMID: 22687943, DOI: 10.1016/j.semradonc.2012.03.003.Peer-Reviewed Original ResearchConceptsHPV-positive diseaseNeck carcinomaClinical trialsHuman papillomavirus-negative headOncogenic human papillomavirus (HPV) infectionPack-year smoking historyCurative treatment regimensHPV-negative diseaseHuman Papillomavirus–PositiveHuman papillomavirus infectionSquamous cell headProspective clinical trialsTraditional risk factorsSquamous cell carcinomaHPV-negative headCurrent clinical trialsCombination of radiationIntermediate riskPapillomavirus infectionSmoking historySystemic therapyTreatment regimensCell carcinomaTransoral surgeryNeck cancer