2008
Regulation of cytoplasmic and nuclear PTEN levels by human papillomavirus (HPV) type 16 E6 and E7 oncogenes in HPV16+ oropharyngeal cancer cell line
Psyrri A, Sasaki C, Burtness B, Rampias T. Regulation of cytoplasmic and nuclear PTEN levels by human papillomavirus (HPV) type 16 E6 and E7 oncogenes in HPV16+ oropharyngeal cancer cell line. Journal Of Clinical Oncology 2008, 26: 6034-6034. DOI: 10.1200/jco.2008.26.15_suppl.6034.Peer-Reviewed Original ResearchGene expression differences associated with silencing of E6 and E7 viral oncogenes in HPV16 + oropharyngeal cancer cell lines
Rampias T, Sasaki C, Burtness B, Psyrri A. Gene expression differences associated with silencing of E6 and E7 viral oncogenes in HPV16 + oropharyngeal cancer cell lines. Journal Of Clinical Oncology 2008, 26: 6009-6009. DOI: 10.1200/jco.2008.26.15_suppl.6009.Peer-Reviewed Original Research
1998
Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.
Pizzorno G, Yee L, Burtness BA, Marsh JC, Darnowski JW, Chu MY, Chu SH, Chu E, Leffert JJ, Handschumacher RE, Calabresi P. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. Clinical Cancer Research 1998, 4: 1165-75. PMID: 9607574.Peer-Reviewed Original ResearchConceptsPreclinical studiesDose levelsUridine concentrationPhase I clinical trialGrade 1 constipationGrade 1 elevationGrade 1 fatigueGrade 1 feverGrade 2 anemiaOral dose levelsSingle oral doseTreatment of patientsPlasma uridine concentrationBiochemical end pointsFirst-order clearanceAverage peak concentrationCancer cell linesAdvanced cancerOral dosePlasma levelsPlasma uridineClinical trialsPlasma concentrationsSustained elevationTracer dose