2024
Advances in predicting breast cancer driver mutations: Tools for precision oncology (Review)
Hao W, Rajendran B, Cui T, Sun J, Zhao Y, Palaniyandi T, Selvam M. Advances in predicting breast cancer driver mutations: Tools for precision oncology (Review). International Journal Of Molecular Medicine 2024, 55: 6. PMID: 39450552, PMCID: PMC11537269, DOI: 10.3892/ijmm.2024.5447.Peer-Reviewed Original ResearchConceptsDisease-free survivalBreast cancerPrecision medicine approachAvailability of high-throughput sequencingPrecision oncologyTherapeutic optionsDriver mutationsDisease-free survival of patientsCancer driver gene identificationDriver gene identificationMedicine approachHigh-throughput sequencingSurvival of patientsTargeted therapeutic optionsFraction of patientsCancer driver mutationsTargeted therapeutic approachesBreast cancer treatmentIdentification of driver mutationsBreast cancer mutationsModern era of medicineCancer-specific biomarkersGene identificationCancer DatabaseCancer mutationsWnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis
Luan Y, Hu J, Wang Q, Wang X, Li W, Qu R, Yang C, Rajendran B, Zhou H, Liu P, Zhang N, Shi Y, Liu Y, Tang W, Lu J, Wu D. Wnt5 controls splenic myelopoiesis and neutrophil functional ambivalency during DSS-induced colitis. Cell Reports 2024, 43: 113934. PMID: 38461416, PMCID: PMC11064424, DOI: 10.1016/j.celrep.2024.113934.Peer-Reviewed Original ResearchCD8<sup>+</sup> T cell activationNeutrophil productionNeutrophil plasticitySplenic extramedullary myelopoiesisFamily member 5T cell activationInnate immune cellsSplenic stromal cellsDSS-induced colitisAnti-inflammatory protectionCD101 expressionPro-inflammatory activitySplenic myelopoiesisExtramedullary myelopoiesisBone marrowImmune cellsSplenic neutrophilsMember 5Autoimmune diseasesInflammatory outcomesCell activationStromal cellsColitisSplenic productionElevated numbersThe CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
Liao X, Li W, Zhou H, Rajendran B, Li A, Ren J, Luan Y, Calderwood D, Turk B, Tang W, Liu Y, Wu D. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nature Communications 2024, 15: 603. PMID: 38242867, PMCID: PMC10798966, DOI: 10.1038/s41467-024-44885-0.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsCancer immunotherapyMouse CD8+ T cellsAnti-tumor immunityTumor growth inhibition abilityAnti-tumor effectsInhibition of neddylationCD8Effector functionsTCR stimulationIL2 signalingCentral signaling pathwaysCore signaling pathwaysEffector activityNegative regulatory mechanismsTranslational implicationsImmunotherapyGrowth inhibition abilityCytokine signalingTCRProteomic alterationsSignaling pathwayCancerCRISPR-based screens
2023
606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy
Srivastava M, Gayevskiy V, Ma V, Estay I, Rodas M, Rajendran B, Hoang T, Ballinger M, Amin R, Herbst R, Marinis F, Giaccone G, Jassem J, Spigel D, Schalper K, Koeppen H, Shames D, Johnston R, Giltnane J, Nabet B. 606 IMpower110: Tertiary lymphoid structures (TLS) and clinical outcomes in advanced non-small cell lung cancer (NSCLC) treated with first-line atezolizumab or chemotherapy. 2023, a690-a690. DOI: 10.1136/jitc-2023-sitc2023.0606.Peer-Reviewed Original ResearchBiomarkers and biosensors for early cancer diagnosis, monitoring and prognosis
Wahab M, Palaniyandi T, Ravi M, viswanathan S, Baskar G, Surendran H, Gangadharan S, Rajendran B. Biomarkers and biosensors for early cancer diagnosis, monitoring and prognosis. Pathology - Research And Practice 2023, 250: 154812. PMID: 37741139, DOI: 10.1016/j.prp.2023.154812.Peer-Reviewed Original ResearchEarly cancer diagnosisBiosensorEarly cancer detectionCancer biomarkersChip modelSuch biomarkersEngineering technologyBiological samplesCancer typesRecent advancementsEarly detectionNucleic acidsEarly diagnostic markerCancer detectionDevelopment of technologyGlobal socioeconomic impactTumor cell DNAProstate cancerMajor challengeBiomedical engineering technologyTherapeutic outcomesDetectionDiagnostic markerTechnologyParticular cancer typesPharmacological effect of gold nanoparticles from red algae Halymenia venusta on A549 cell line
Baskar G, Palaniyandi T, Viswanathan S, Wahab M, Surendran H, Ravi M, Rajendran B, Govindasamy G, Sivaji A, Kaliamoorthy S. Pharmacological effect of gold nanoparticles from red algae Halymenia venusta on A549 cell line. Inorganic Chemistry Communications 2023, 155: 111005. DOI: 10.1016/j.inoche.2023.111005.Peer-Reviewed Original ResearchUltra-violet spectroscopyGold nanoparticlesSurface plasmon resonanceFourier transform infra-red spectroscopy (FTIR) analysesX-ray diffraction spectroscopyStable gold nanoparticlesInfra-red spectroscopy analysisGreen synthesisDiffraction spectroscopyFree radical scavenging capabilityRadical scavenging capabilitySpectroscopy analysisAnalytical techniquesCrystalline structurePlasmon resonanceNanoparticlesA549 cell lineReactive oxygen species assaysPromising anti-cancer potentialAntiproliferative activityElectron microscopyAntimicrobial activitySpectroscopyScavenging capabilityAnti-cancer potentialRole of homeobox d10 gene targeted signaling pathways in cancers
Surendran H, Palaniyandi T, Natarajan S, Hari R, Viwanathan S, Baskar G, Abdul Wahab M, Ravi M, Rajendran B. Role of homeobox d10 gene targeted signaling pathways in cancers. Pathology - Research And Practice 2023, 248: 154643. PMID: 37406379, DOI: 10.1016/j.prp.2023.154643.Peer-Reviewed Original ResearchConceptsTranscription factorsHomeobox gene familyHomeotic transcription factorsGene expression changesTumor suppressor geneD10 geneGene familyHomeobox genesCancer signalingOrgan developmentTissue homeostasisGene expressionExpression changesSignaling pathwaysCell differentiationSuppressor geneFunctional interactionGenesHOXD10 geneCancer treatment targetHOXD10Pathway dysregulationTherapeutic resistancePathwayMolecule actionRecent and advanced therapy for oral cancer
Baskar G, Palaniyandi T, Viswanathan S, Wahab M, Surendran H, Ravi M, Sivaji A, Rajendran B, Natarajan S, Govindasamy G. Recent and advanced therapy for oral cancer. Biotechnology And Bioengineering 2023, 120: 3105-3115. PMID: 37243814, DOI: 10.1002/bit.28452.Peer-Reviewed Original ResearchInsights of Endocytosis Signaling in Health and Disease
Pathak C, Vaidya F, Waghela B, Jaiswara P, Gupta V, Kumar A, Rajendran B, Ranjan K. Insights of Endocytosis Signaling in Health and Disease. International Journal Of Molecular Sciences 2023, 24: 2971. PMID: 36769293, PMCID: PMC9918140, DOI: 10.3390/ijms24032971.Peer-Reviewed Original ResearchConceptsEndocytic machineryPlasma membraneCellular defenseFundamental cellular machinerySignal transduction modulesDifferent cellular compartmentsVital physiological processesProcess of endocytosisEndocytic proteinsIndependent endocytosisEndocytosis machineryTransduction modulesEukaryotic cellsCaveolar pathwayCellular machineryMammalian cellsEndocytic pathwayCell divisionCellular compartmentsComplex proteinsFunctional characterizationPhysiological processesMachinery resultsHuman diseasesEndocytosisIntegrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations
Ren J, Qu R, Rahman N, Lewis J, King A, Liao X, Mirza F, Carlson K, Huang Y, Gigante S, Evans B, Rajendran B, Xu S, Wang G, Foss F, Damsky W, Kluger Y, Krishnaswamy S, Girardi M. Integrated transcriptome and trajectory analysis of cutaneous T-cell lymphoma identifies putative precancer populations. Blood Advances 2023, 7: 445-457. PMID: 35947128, PMCID: PMC9979716, DOI: 10.1182/bloodadvances.2022008168.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaMalignant CTCL cellsDiverse transcriptomic profilesT cellsSingle-cell RNACTCL cellsDevelopment of CTCLIntegrated transcriptomeT-cell receptor sequencingT cell exhaustion phenotypeCommon antigenic stimulusPeripheral blood CD4Transcriptomic profilesGene expressionT-cell lymphomaIntegrative analysisPotential therapeutic targetProliferation advantageLimited diversityBlood CD4Blood involvementMutation levelsExhaustion phenotypeWorse prognosisAntigenic stimulusGreen synthesis of gold nanoparticles using Halymenia pseudofloresii extracts and their antioxidant, antimicrobial, and anti-cancer activities
Palaniyandi T, Viswanathan S, Prabhakaran P, Baskar G, Wahab M, Sivaji A, Ravi M, Rajendran B, Moovendhan M, Surendran H, Kumarasamy S. Green synthesis of gold nanoparticles using Halymenia pseudofloresii extracts and their antioxidant, antimicrobial, and anti-cancer activities. Biomass Conversion And Biorefinery 2023, 1-12. DOI: 10.1007/s13399-023-03873-y.Peer-Reviewed Original ResearchSurface plasmon resonance peakGold nanoparticlesUV spectroscopyFormation of nanoparticlesPlasmon resonance peakX-ray diffraction analysisNumerous biomedical applicationsReactive oxygen species (ROS) generation assaysGreen synthesisAuNPs morphologyAnticancer screeningSynthesized nanoparticlesCarboxylic groupsEfficient antibacterial effectGreen methodPotential cytotoxic activityAnticancer applicationsFTIR analysisDiffraction analysisBioactive moleculesBiomedical purposesNanoparticlesBiomedical applicationsScanning electron microscope analysisGlioblastoma cancer cellsBiosynthesis of iron nanoparticles using brown algae Spatoglossum asperum and its antioxidant and anticancer activities through in vitro and in silico studies
Palaniyandi T, Baskar G, V B, Viswanathan S, Abdul Wahab M, Govindaraj M, Sivaji A, Rajendran B, Kaliamoorthy S. Biosynthesis of iron nanoparticles using brown algae Spatoglossum asperum and its antioxidant and anticancer activities through in vitro and in silico studies. Particulate Science And Technology 2023, 41: 916-929. DOI: 10.1080/02726351.2022.2159900.Peer-Reviewed Original ResearchIron nanoparticlesX-ray diffraction spectroscopy analysisSpectroscopy analysisSurface plasmon resonance peakFourier Transform Infrared Spectroscopy (FTIR) analysisTransform Infrared Spectroscopy analysisSynthesized iron nanoparticlesAnticancer activityPlasmon resonance peakUV-visible spectraIron oxide nanoparticlesInfrared Spectroscopy analysisMetal nanoparticlesFerrous ion oxidationIon oxidationFunctional groupsOxide nanoparticlesMolecular dockingNanoparticlesFree radical scavenging activityBiomedical applicationsPotential antioxidant activityCrystalline structureGlioblastoma cancer cellsRadical scavenging activitySynthesis, characterization, cytotoxicity, and antimicrobial studies of green synthesized silver nanoparticles using red seaweed Champia parvula
Viswanathan S, Palaniyandi T, Shanmugam R, Karunakaran S, Pandi M, Wahab M, Baskar G, Rajendran B, Sivaji A, Moovendhan M. Synthesis, characterization, cytotoxicity, and antimicrobial studies of green synthesized silver nanoparticles using red seaweed Champia parvula. Biomass Conversion And Biorefinery 2023, 14: 7387-7400. DOI: 10.1007/s13399-023-03775-z.Peer-Reviewed Original ResearchCP-AgNPsSilver nanoparticlesSurface plasmonic resonance bandPlasmonic resonance bandX-ray diffraction analysisFT-IR analysisEco-friendly techniqueMetal nanoparticlesSpectroscopic techniquesAntimicrobial studiesDrug carriersUV spectroscopyAmine compoundsHigh antimicrobial activityFree radical scavenging abilitySurface chargeDiffraction analysisNanoparticlesResonance bandBioactive moleculesAlgae extractRadical scavenging abilityCrystalline structurePotential analysisAnticancer activity
2022
Prospect and retrospect of 3D bio-printing
Prabhakaran P, Palaniyandi T, Kanagavalli B, kumar V, Hari R, Sandhiya V, Baskar G, Rajendran B, Sivaji A. Prospect and retrospect of 3D bio-printing. Acta Histochemica 2022, 124: 151932. PMID: 36027838, DOI: 10.1016/j.acthis.2022.151932.Peer-Reviewed Original ResearchGene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies
Pranav P, Palaniyandi T, Baskar G, Ravi M, Rajendran B, Sivaji A, Ranganathan M. Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies. Acta Histochemica 2022, 124: 151910. PMID: 35667159, DOI: 10.1016/j.acthis.2022.151910.Peer-Reviewed Original ResearchConceptsBreast cancerOrganoid culturesGene expression changesPatient-derived biopsiesBreast cancer biopsiesExpression of ErbB2Progesterone receptor geneCancer cell linesExpression changesSuch cancersPatient biopsiesCancer biopsiesSolid tumorsBiopsyMalignant cellsCancerGene expressionMagnitude of expressionHuman cancersCancer therapyReceptor geneCell linesSuch organoidsCancer researchFunctional physiologyBiogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer
Viswanathan S, Palaniyandi T, Kannaki P, Shanmugam R, Baskar G, Rahaman A, Paul L, Rajendran B, Sivaji A. Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer. Particulate Science And Technology 2022, 41: 241-249. DOI: 10.1080/02726351.2022.2074926.Peer-Reviewed Original ResearchCP-AuNPsGold nanoparticlesSurface plasmon resonance peakTransmission electron microscopeBiocompatible gold nanoparticlesHigh anti-cancer potentialPlasmon resonance peakX-ray diffraction spectraUV spectroscopy analysisBiogenic synthesisBiogenic methodSpectroscopic techniquesOrganic compoundsCrystal natureSpectroscopy analysisFree radical scavenging abilityRadical scavenging abilityScanning electron microscope analysisDiffraction spectraAnti-cancer activityNanoparticlesElectron microscope analysisAnti-cancer potentialElectron microscopeRed marineDevelopment of patient derived organoids for cancer drug screening applications
Baskar G, Palaniyandi T, Viswanathan S, Rajendran B, Ravi M, Sivaji A. Development of patient derived organoids for cancer drug screening applications. Acta Histochemica 2022, 124: 151895. PMID: 35486967, DOI: 10.1016/j.acthis.2022.151895.Peer-Reviewed Original ResearchConceptsPre-clinical modelsEx vivo tissue cultureDevelopment of patientsCancer researchStem cellsVivo tissue culturePatient responseAbnormal cell growthProgenitor cellsHigh-throughput drug screeningVivo propertiesOrganoidsHuman organoidsPluripotent stem cellsCell growthDrug screening applicationsDrug screeningThroughput drug screeningEmbryonic stem cellsTissueCellsTissue cultureEffective recapitulationPatientsClinic
2021
Biomedical potential of silver nanoparticles capped with active ingredients of Hypnea valentiae, red algae species
Viswanathan S, Palaniyandi T, Shanmugam R, M T, Rajendran B, Sivaji A. Biomedical potential of silver nanoparticles capped with active ingredients of Hypnea valentiae, red algae species. Particulate Science And Technology 2021, 40: 686-696. DOI: 10.1080/02726351.2021.1992059.Peer-Reviewed Original ResearchSilver nanoparticlesTransmission electron microscopeFace-centered cubic crystalline structureUltraviolet-visible spectroscopyX-ray diffraction analysisExcellent anti-cancer activityCubic crystalline structureAnti-cancer activitySignificant antibacterial activityAmine groupsGreen methodA549 lung cancer cell lineFourier transformFree radical scavenging abilityNanoparticlesDiffraction analysisAverage sizeBiomedical potentialRadical scavenging abilityCrystalline structureElectron microscopeHT-29 human colon cancerRed algae speciesAntibacterial activityStrong free radical scavenging abilityMolecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
Ding R, Chen P, Rajendran B, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong A, Valecha M, Yang E, Su S, Choi T, Liu S, Chan K, Yang L, Wu J, Miao K, Chen Q, Shim J, Xu X, Deng C. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics. Nature Communications 2021, 12: 3046. PMID: 34031426, PMCID: PMC8144567, DOI: 10.1038/s41467-021-23379-3.Peer-Reviewed Original ResearchConceptsSarcomatoid carcinomaEpithelial-mesenchymal transitionNasopharyngeal carcinomaCarcinoma subtypesNeck cancer typesPatient-derived organoidCRT regimensDistinct molecular featuresMalignant headHigh morbidityTreatment regimensTherapeutic responseEC subtypesPathogenic mechanismsDrug responsivenessEGFR inhibitorsNPC subtypesCancer typesSubtypesCarcinomaPrecision oncologyDrug testsMolecular landscapeRegimensMicrotubule inhibitorsAccelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform
Xing F, Liu Y, Huang S, Lyu X, Su S, Chan U, Wu P, Yan Y, Ai N, Li J, Zhao M, Rajendran B, Liu J, Shao F, Sun H, Choi T, Zhu W, Luo G, Liu S, Xu D, Chan K, Zhao Q, Miao K, Luo K, Ge W, Xu X, Wang G, Liu T, Deng C. Accelerating precision anti-cancer therapy by time-lapse and label-free 3D tumor slice culture platform. Theranostics 2021, 11: 9415-9430. PMID: 34646378, PMCID: PMC8490519, DOI: 10.7150/thno.59533.Peer-Reviewed Original ResearchConceptsAnti-cancer therapyNew pre-clinical modelsDay of surgeryPre-clinical modelsRNA sequence analysisHigh-efficacy drugsAnti-cancer drug efficacyPD-1PD-L1Personalized medicineBlockade assayAnti-cancer drug discoveryImmune componentsOriginal tumorAutofluorescence featuresDrug efficacyHistological analysisPrecision anti-cancer therapyCancer treatmentDrug responseHigh-throughput drug screeningDrug discoveryTherapyEfficacyCell-based high-throughput drug screening