2018
Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study. Toxins 2018, 10: 401. PMID: 30274305, PMCID: PMC6215171, DOI: 10.3390/toxins10100401.Peer-Reviewed Original ResearchConceptsRestless legs syndromePain scoresCrossover studyLegs syndromePlacebo-controlled crossover studyDouble-blind placeboPatient Global ImpressionVisual analog scalePrevious smaller studiesCommon movement disorderQuality of lifeIncobotulinumtoxin APlacebo groupRLS symptomsAnalog scaleGlobal ImpressionOnabotulinumtoxin ALife QuestionnaireTibialis anteriorBotulinum toxinNormal salineMovement disordersRLS scoresSmall studyFemoris muscleBotulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach. Parkinsonism & Related Disorders 2018, 56: 65-69. PMID: 29929813, DOI: 10.1016/j.parkreldis.2018.06.019.Peer-Reviewed Original ResearchConceptsHand weaknessEssential hand tremorDouble-blind placebo-controlled studyEssential tremorAdministration of onabotulinumtoxinASevere hand weaknessPlacebo-controlled studyClinical rating scoresHand tremorRating scoresParkinson's disease tremorIncobotulinumtoxinA injectionsCrossover trialPatients' perceptionsBotulinum toxinTreatment efficacyClinical practiceHand strengthForearm musclesTremor severityClinical scalesTremorWeeksTreatmentInjection
2017
Botulinum Toxin in Parkinson Disease Tremor A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum Toxin in Parkinson Disease Tremor A Randomized, Double-Blind, Placebo-Controlled Study With a Customized Injection Approach. Mayo Clinic Proceedings 2017, 92: 1359-1367. PMID: 28789780, DOI: 10.1016/j.mayocp.2017.06.010.Peer-Reviewed Original ResearchConceptsDisease Rating ScaleHand weaknessPatients' perceptionsUnified Parkinson's Disease Rating ScaleParkinson's Disease Rating ScaleAdministration of onabotulinumtoxinASevere hand weaknessUse of onabotulinumtoxinAPatient Global ImpressionClinical rating scoresTreatment of tremorParkinson's disease tremorIncobotulinumtoxinA injectionsCrossover trialGlobal ImpressionGrip strengthRest tremorBotulinum toxinPD tremorPostural tremorTreatment efficacyClinical practiceSignificant improvementEssential tremorHand strength
2016
Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain
Machado D, Kumar A, Jabbari B. Abobotulinum Toxin A in the Treatment of Chronic Low Back Pain. Toxins 2016, 8: 374. PMID: 27983689, PMCID: PMC5198568, DOI: 10.3390/toxins8120374.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painVisual analog scaleOswestry Low Back Pain Disability QuestionnaireAbobotulinum toxin ABack painQuality of lifeToxin APain Disability QuestionnairePatient Global ImpressionLevel of painPrimary outcome measureProportion of respondersStrong analgesic effectAbobotulinum toxinOswestry scorePlacebo groupAnalgesic effectDisability QuestionnaireMore patientsStudy cohortAnalog scaleGlobal ImpressionMultifactorial pathophysiologyPatients' perceptionsIncobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer Patients
Rostami R, Mittal SO, Radmand R, Jabbari B. Incobotulinum Toxin-A Improves Post-Surgical and Post-Radiation Pain in Cancer Patients. Toxins 2016, 8: 22. PMID: 26771640, PMCID: PMC4728544, DOI: 10.3390/toxins8010022.Peer-Reviewed Original ResearchConceptsVisual analog scaleCancer patientsGlobal ImpressionSite of radiationPoor general conditionPatient Global ImpressionLocation of painIncobotulinum toxin AFocal painAnalgesic medicationPain controlAnalog scaleSkin reactionsToxin ALocal cancerPatientsSignificant improvementPainSurgeryChange ScaleResearch protocolSignificant satisfactionGeneral conditionMedicationsFollow
2012
OnabotulinumtoxinA for Treatment of Focal Cancer Pain After Surgery and/or Radiation
Mittal S, Machado DG, Jabbari B. OnabotulinumtoxinA for Treatment of Focal Cancer Pain After Surgery and/or Radiation. Pain Medicine 2012, 13: 1029-1033. PMID: 22776097, DOI: 10.1111/j.1526-4637.2012.01437.x.Peer-Reviewed Original ResearchConceptsQuality of lifeCancer patientsCancer painLocal treatmentEffect of onabotulinumtoxinAPatient global assessmentAreas of surgeryFocal painMasseter injectionLocal surgeryPain reliefPain areaRepeat injectionsRepeat treatmentPainPatientsSecond injectionSignificant improvementOnabotulinumtoxinAGlobal assessmentSurgeryJaw musclesTreatmentInjectionReliefIpsilateral synkinesia involves the supplementary motor area
Salardini A, Narayanan NS, Arora J, Constable T, Jabbari B. Ipsilateral synkinesia involves the supplementary motor area. Neuroscience Letters 2012, 523: 135-138. PMID: 22759337, PMCID: PMC3836003, DOI: 10.1016/j.neulet.2012.06.060.Peer-Reviewed Original ResearchConceptsSupplementary motor areaMotor areaInvoluntary coordinationFoot motor corticesHand motor taskMotor cortexMagnetic resonance imaging dataRare disorderInvoluntary movementsSynkinesiaVoluntary movementMotor tasksControl participantsFunctional magnetic resonance imaging (fMRI) dataPatientsImaging dataRhythmic tasksCentral roleCortex
2010
Botulinum Toxin A for Treatment of Allodynia of Complex Regional Pain Syndrome: A Pilot Study
Safarpour D, Salardini A, Richardson D, Jabbari B. Botulinum Toxin A for Treatment of Allodynia of Complex Regional Pain Syndrome: A Pilot Study. Pain Medicine 2010, 11: 1411-1414. PMID: 20609130, DOI: 10.1111/j.1526-4637.2010.00897.x.Peer-Reviewed Original ResearchConceptsComplex regional pain syndromeRegional pain syndromeBotulinum toxin APain syndromeToxin AOpen-label protocolPain Impact QuestionnairePlacebo-controlled protocolTreatment of allodyniaBrief Pain InventoryMcGill Pain QuestionnaireGlobal satisfaction scaleAllodynic areaAllodynic skinPain InventoryPain QuestionnaireImpact QuestionnaireSubcutaneous administrationPatientsSatisfaction ScaleAllodyniaPilot studySyndromeBoNTTreatment
2009
Botulinum Neurotoxin-A for Treatment of Refractory Neck Pain: A Randomized, Double-Blind Study
Miller D, Richardson D, Eisa M, Bajwa RJ, Jabbari B. Botulinum Neurotoxin-A for Treatment of Refractory Neck Pain: A Randomized, Double-Blind Study. Pain Medicine 2009, 10: 1012-1017. PMID: 19594841, DOI: 10.1111/j.1526-4637.2009.00658.x.Peer-Reviewed Original ResearchConceptsVisual analog scaleRefractory neck painNeck painExcellent respondersPrimary outcomeMean visual analog scaleAdministration of BoNTEfficacy of BoNTUnits of BoNTChronic neck painPlacebo-controlled studyDouble-blind studyImprovement of ADLBotulinum neurotoxinPlacebo groupAnalgesic effectBotox groupFrequency questionnaireSecondary outcomesPain intensityPain localizationPain QuestionnaireAnalog scaleBlinded studyAnimal studies
2008
Regional Expression of NAD(P)H Oxidase and Superoxide Dismutase in the Brain of Rats with Neurogenic Hypertension
Bai Y, Jabbari B, Ye S, Campese VM, Vaziri ND. Regional Expression of NAD(P)H Oxidase and Superoxide Dismutase in the Brain of Rats with Neurogenic Hypertension. American Journal Of Nephrology 2008, 29: 483-492. PMID: 19047792, PMCID: PMC2821947, DOI: 10.1159/000178817.Peer-Reviewed Original ResearchConceptsKidney cortexInjection of phenolCentral noradrenergic activityBrain of ratsRats 4 weeksAssociated hypertensionChronic hypertensionNeurogenic hypertensionArterial pressureBlood pressureNoradrenergic activityNoradrenergic controlLateral ventricleHypertensionRole of superoxideSingle injectionMaladaptive changesPathway activationReactive oxygen speciesRatsUpregulationOxidase subunitsBrainSuperoxide dismutaseCortexSensory physiology assessed by evoked potentials in survivors of poliomyelitis
Prokhorenko OA, Vasconcelos OM, Lupu VD, Campbell WW, Jabbari B. Sensory physiology assessed by evoked potentials in survivors of poliomyelitis. Muscle & Nerve 2008, 38: 1266-1271. PMID: 18816600, DOI: 10.1002/mus.21093.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAgedAged, 80 and overAtrophyBrainCohort StudiesDisability EvaluationDisease ProgressionElectric StimulationElectroencephalographyEvoked Potentials, SomatosensoryFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural ConductionPoliomyelitisPostpoliomyelitis SyndromeSensation DisordersSensory Receptor CellsSeverity of Illness IndexSpinal CordSurvivorsConceptsMagnetic resonance imagingPolio survivorsLower limb SEPsPatches of atrophySurvivors of poliomyelitisUpper limb SEPsProportion of patientsAbnormal SEPsElectrographic findingsSensory lossMean ageSensory deficitsSpinal cordSensory abnormalitiesSensory impairmentPatientsSensory pathwaysSensory functionSEP studiesResonance imagingPoliomyelitisSurvivorsSensory problemsSEPsFurther studiesTreatment of Painful Limbs/Moving Extremities with Botulinum Toxin Type A Injections
Eisa M, Singer C, Sengun C, Russel A, Jabbari B, Papapetropoulos S. Treatment of Painful Limbs/Moving Extremities with Botulinum Toxin Type A Injections. European Neurology 2008, 60: 104-106. PMID: 18552499, DOI: 10.1159/000138962.Peer-Reviewed Original Research
2007
Physiology of the motor cortex in polio survivors
Lupu VD, Danielian L, Johnsen JA, Vasconcelos OM, Prokhorenko OA, Jabbari B, Campbell WW, Floeter MK. Physiology of the motor cortex in polio survivors. Muscle & Nerve 2007, 37: 177-182. PMID: 17990291, DOI: 10.1002/mus.20913.Peer-Reviewed Original ResearchConceptsCentral motor conduction timeTranscranial magnetic stimulationPolio survivorsMotor cortexPaired-pulse transcranial magnetic stimulationsMotor conduction timeMotor cortex excitabilityPost-polio syndromeTibialis anterior muscleMaximal motorCortex excitabilityTwitch interpolationCentral fatigueCorticospinal systemMaximal contractionHealthy controlsMotor neuronsAnterior muscleConduction timeMagnetic stimulationFunctional changesRecruitment curvesPolioSurvivorsCortexDeep brain stimulation in Tourette's syndrome
Bajwa RJ, de Lotbinière AJ, King RA, Jabbari B, Quatrano S, Kunze K, Scahill L, Leckman JF. Deep brain stimulation in Tourette's syndrome. Movement Disorders 2007, 22: 1346-1350. PMID: 17580320, DOI: 10.1002/mds.21398.Peer-Reviewed Original ResearchConceptsDeep brain stimulationBilateral deep brain stimulationTourette syndromeBrain stimulationIntractable Tourette syndromeProgressive neurological impairmentAdult patientsSevere ticsObsessive-compulsive disorderNeurological impairmentMotor ticsMedial partSyndromeHead jerkThalamusStimulationPatientsImpairmentGood effect
2006
Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain
Campese VM, Sindhu RK, Ye S, Bai Y, Vaziri ND, Jabbari B. Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain. Brain Research 2006, 1134: 27-32. PMID: 17196179, DOI: 10.1016/j.brainres.2006.11.067.Peer-Reviewed Original ResearchConceptsEndothelial NO synthaseSoluble guanylate cyclaseNeuronal NOSNitric oxideGlutathione peroxidaseNO synthaseRat brainSuperoxide dismutaseActivation of NOSNormal rat brainImportance of NOArterial pressureCytoplasmic superoxide dismutaseSympathetic activityCerebral circulationBrain perfusionCentral regulationBrain functionGuanylate cyclaseNO receptorMedullaNOSPonsAntioxidant enzymesRelative expression
1993
Contrast agent overdose causing brain retention of contrast, seizures and parkinsonism.
May E, Ling G, Geyer C, Jabbari B. Contrast agent overdose causing brain retention of contrast, seizures and parkinsonism. Neurology 1993, 43: 836-8. PMID: 8469350, DOI: 10.1212/wnl.43.4.836.Peer-Reviewed Original Research
1981
Paroxysmal, rhythmic lingual movements and chronic epilepsy.
Jabbari B, Coker S. Paroxysmal, rhythmic lingual movements and chronic epilepsy. Neurology 1981, 31: 1364-7. PMID: 7202144, DOI: 10.1212/wnl.31.10.1364.Peer-Reviewed Original Research