Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier.
Jing W, Jabbari B, Vaziri ND. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. American Journal Of Translational Research 2018, 10: 2137-2147. PMID: 30093950, PMCID: PMC6079125.Peer-Reviewed Original ResearchImpaired blood-brain barrierBlood-brain barrierCerebral cortexBrain barrierNF-κBBody weightChronic kidney disease (CKD) resultsInducible NO synthase isoformCentral nervous system disordersOxidative stressElevated serum ureaPro-inflammatory moleculesEndothelial junctional complexesNuclear translocationReduced body weightMale Sprague-DawleyTissue oxidative stressNervous system disordersNO synthase (NOS) isoformsCKD groupCKD ratsFibrosis mediatorsWestern blot analysisRenal functionArterial pressure